{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T18:10:54Z","timestamp":1784916654535,"version":"3.55.0"},"reference-count":78,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["493410640"],"award-info":[{"award-number":["493410640"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["WE 2720\/5\u20101"],"award-info":[{"award-number":["WE 2720\/5\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The velocity of axonal impulse propagation is facilitated by myelination and axonal diameters. Both parameters are frequently impaired in peripheral nerve disorders, but it is not known if the diameters of myelinated axons affect the liability to injury or the efficiency of functional recovery. Mice lacking the adaxonal myelin protein chemokine\u2010like factor\u2010like MARVEL\u2010transmembrane domain\u2010containing family member\u20106 (CMTM6) specifically from Schwann cells (SCs) display appropriate myelination but increased diameters of peripheral axons. Here we subjected <jats:italic>Cmtm6<\/jats:italic>\u2010cKo mice as a model of enlarged axonal diameters to a mild sciatic nerve compression injury that causes temporarily reduced axonal diameters but otherwise comparatively moderate pathology of the axon\/myelin\u2010unit. Notably, both of these pathological features were worsened in <jats:italic>Cmtm6<\/jats:italic>\u2010cKo compared to genotype\u2010control mice early post\u2010injury. The increase of axonal diameters caused by CMTM6\u2010deficiency thus does not override their injury\u2010dependent decrease. Accordingly, we did not detect signs of improved regeneration or functional recovery after nerve compression in <jats:italic>Cmtm6<\/jats:italic>\u2010cKo mice; depleting CMTM6 in SCs is thus not a promising strategy toward enhanced recovery after nerve injury. Conversely, the exacerbated axonal damage in <jats:italic>Cmtm6<\/jats:italic>\u2010cKo nerves early post\u2010injury coincided with both enhanced immune response including foamy macrophages and SCs and transiently reduced grip strength. Our observations support the concept that larger peripheral axons are particularly susceptible toward mechanical trauma.<\/jats:p>","DOI":"10.1002\/glia.24568","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T08:34:34Z","timestamp":1718786074000},"page":"1572-1589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Myelinated peripheral axons are more vulnerable to mechanical trauma in a model of enlarged axonal diameters"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6673-0714","authenticated-orcid":false,"given":"Vasiliki\u2010Ilya","family":"Gargareta","sequence":"first","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute for Multidisciplinary Sciences  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3794-7295","authenticated-orcid":false,"given":"Stefan A.","family":"Berghoff","sequence":"additional","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute for Multidisciplinary Sciences  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1779-093X","authenticated-orcid":false,"given":"Doris","family":"Krauter","sequence":"additional","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute for Multidisciplinary Sciences  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3787-2043","authenticated-orcid":false,"given":"Sophie","family":"H\u00fcmmert","sequence":"additional","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute for Multidisciplinary Sciences  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6275-5941","authenticated-orcid":false,"given":"Katy L. H.","family":"Marshall\u2010Phelps","sequence":"additional","affiliation":[{"name":"Centre for Discovery Brain Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2902-7165","authenticated-orcid":false,"given":"Wiebke","family":"M\u00f6bius","sequence":"additional","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute for Multidisciplinary Sciences  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8724-9666","authenticated-orcid":false,"given":"Klaus\u2010Armin","family":"Nave","sequence":"additional","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute for Multidisciplinary Sciences  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5323-7958","authenticated-orcid":false,"given":"Robert","family":"Fledrich","sequence":"additional","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute for Multidisciplinary Sciences  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7710-5738","authenticated-orcid":false,"given":"Hauke B.","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute for Multidisciplinary Sciences  G\u00f6ttingen Germany"},{"name":"Biology and Psychology University of G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9925-7249","authenticated-orcid":false,"given":"Maria A.","family":"Eichel\u2010Vogel","sequence":"additional","affiliation":[{"name":"Department of Neurogenetics Max Planck Institute for Multidisciplinary Sciences  G\u00f6ttingen Germany"},{"name":"Centre for Discovery Brain Sciences University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.812588"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137391"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.06.021"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.22955"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00757-6"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-07311-8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23643"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.10.079"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91637-T"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1482-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.30.051606.094337"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/83348"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00319"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28790-3"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18172-7"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3664"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15587"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201205025"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23705"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001154"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2568-10.2011"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.4.1929"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2797"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201503019"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/59.11.1002"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01899-x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10692"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1580"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0262"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.61"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22957"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270874"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23532"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00033"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.5115\/acb.2011.44.1.41"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.723"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002937"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1653-y"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.03.047"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.03.009"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00108"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.2.308"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf072"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2013.12.002"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02462-6"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1710566114"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2010.00257.x"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hcl.2013.04.002"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23669"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1095862"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759091414551782"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03516-9"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-198711000-00008"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.06.016"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22922"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4321"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2016.07.010"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(72)90215-6"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3281"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22771"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(75)90237-X"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.175042"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/74.4.491"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.08.017"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2019.108367"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201506035"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.30.051606.094354"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903230207"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181efa658"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8027.2000.00026.x"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.62232"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9072-6_20"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.018184"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0618-6"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143491"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.18-06-01953.1998"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1860-14.2014"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2942-18.2019"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.24568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T06:16:45Z","timestamp":1731133005000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.24568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,19]]},"references-count":78,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/glia.24568"],"URL":"https:\/\/doi.org\/10.1002\/glia.24568","archive":["Portico"],"relation":{},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,19]]},"assertion":[{"value":"2024-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}