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In this study, we tested to what extent astrocytes, a type of glial cell, participate in noradrenergic signaling in mouse primary visual cortex (V1). Astrocytes are essential partners of neurons in the central nervous system. They are central to brain homeostasis, but also dynamically regulate neuronal activity, notably by relaying and regulating neuromodulator signaling. Indeed, astrocytes express receptors for multiple neuromodulators, including noradrenaline, but the extent to which astrocytes are involved in noradrenergic signaling remains unclear. To test whether astrocytes are involved in noradrenergic neuromodulation in mice, we employed both short hairpin RNA mediated knockdown as well as pharmacological manipulation of the major noradrenaline receptor in astrocytes, the \u03b11A\u2010adrenoreceptor. Using acute brain slices, we found that the astrocytic \u03b11A\u2010adrenoreceptor subtype contributes to the generation of large intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signals in visual cortex astrocytes, which are generally thought to underlie astrocyte function. To test if reduced \u03b11A\u2010adrenoreceptor signaling in astrocytes affected the function of neuronal circuits in V1, we used both patch\u2010clamp and field potential recordings. These revealed that noradrenergic signaling through the astrocyte \u03b11A\u2010adrenoreceptor is important to not only modulate synaptic activity but also to regulate plasticity in V1, through the potentiation of synaptic responses in circuits involved in visual information processing.\n                  <\/jats:p>","DOI":"10.1002\/glia.24591","type":"journal-article","created":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T01:20:31Z","timestamp":1720833631000},"page":"1955-1973","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The astrocyte\n                    <scp>\u03b11A<\/scp>\n                    \u2010adrenoreceptor is a key component of the neuromodulatory system in mouse visual 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