{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T06:07:59Z","timestamp":1779170879740,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008445","name":"Parkinsonforeningen","doi-asserted-by":"publisher","award":["R53\u2010A1356\u2010B545"],"award-info":[{"award-number":["R53\u2010A1356\u2010B545"]}],"id":[{"id":"10.13039\/100008445","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    DNAJB6 is a suppressor of \u03b1\u2010synuclein aggregation\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    . DNAJB6 is strongly expressed in the brain, and its overall protein expression is altered in neurodegenerative conditions such as Parkinson's Disease (PD) and Multiple System Atrophy (MSA). These two diseases are characterized by accumulation of aggregated \u03b1\u2010synuclein in neurons and oligodendrocytes, respectively. To further explore this, we employed\n                    <jats:italic>post\u2010mortem<\/jats:italic>\n                    normal human brain material to investigate the regional and cell type specific protein expression of DNAJB6. We found that the DNAJB6 protein is ubiquitously expressed across various regions of the brain. Notably, we demonstrate for the first time that DNAJB6 is present in nearly half (41%\u201353%) of the oligodendrocyte population and in the majority (68%\u201380%) of neurons. However, DNAJB6 was only sparsely present in other cell types such as astrocytes and microglia. Given that \u03b1\u2010synuclein aggregation in oligodendrocytes is a hallmark of MSA, we investigated DNAJB6 presence in MSA brains compared to control brains. We found no significant difference in the percentage of oligodendrocytes where DNAJB6 was present in MSA brains relative to control brains. In conclusion, our results reveal an expression of the DNAJB6 protein across various regions of the human brain, and that DNAJB6 is almost exclusively present in neurons and oligodendrocytes. Since prior studies have shown that PD and MSA brains have altered levels of DNAJB6 relative to control brains, DNAJB6 may be an interesting target for drug development.\n                  <\/jats:p>","DOI":"10.1002\/glia.24615","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:30:49Z","timestamp":1725409849000},"page":"2313-2326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>DNAJB6<\/scp>\n                    is expressed in neurons and oligodendrocytes of the human brain"],"prefix":"10.1002","volume":"72","author":[{"given":"J\u00f3nv\u00e1","family":"Hentze","sequence":"first","affiliation":[{"name":"Centre for Neuroscience and Stereology, Bispebjerg\u2010Frederiksberg Hospital University Hospital of Copenhagen  Copenhagen Denmark"},{"name":"Department of Science and Environment Roskilde University  Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0940-3098","authenticated-orcid":false,"given":"Jonas","family":"Folke","sequence":"additional","affiliation":[{"name":"Centre for Neuroscience and Stereology, Bispebjerg\u2010Frederiksberg Hospital University Hospital of Copenhagen  Copenhagen Denmark"},{"name":"Copenhagen Centre for Translational Research, Bispebjerg\u2010Frederiksberg Hospital University Hospital of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Aznar","sequence":"additional","affiliation":[{"name":"Centre for Neuroscience and Stereology, Bispebjerg\u2010Frederiksberg Hospital University Hospital of Copenhagen  Copenhagen Denmark"},{"name":"Copenhagen Centre for Translational Research, Bispebjerg\u2010Frederiksberg Hospital University Hospital of Copenhagen  Copenhagen 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