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Although most heme is found complexed to hemoglobin in red blood cells, surprisingly, we found that\n                    <jats:italic>Slc48a1<\/jats:italic>\n                    , encoding the heme transporter Hrg1, is expressed at higher levels in OLs than any other cell type in rodent and humans. We confirmed in situ that\n                    <jats:italic>Hrg1<\/jats:italic>\n                    is expressed in OLs but not their precursors (OPCs) and found that Hrg1 proteins in CNS white matter co\u2010localized within myelin sheaths. In older\n                    <jats:italic>Hrg1<\/jats:italic>\n                    null mutant mice we observed reduced expression of myelin associated glycoprotein (Mag) and ultrastructural myelin defects reminiscent of\n                    <jats:italic>Mag<\/jats:italic>\n                    \u2010null animals, suggesting myelin adhesion deficiency. Further, we confirmed reduced myelin iron levels in\n                    <jats:italic>Hrg1<\/jats:italic>\n                    null animals in vivo, and show that OLs in vitro can directly import both the fluorescent heme analogue ZnMP and heme itself, which rescued iron deficiency induced inhibition of OL differentiation in a heme\u2010oxidase\u2010dependent manner. Together these findings indicate OL\n                    <jats:italic>Hrg1<\/jats:italic>\n                    encodes a functional heme transporter required for myelin integrity.\n                  <\/jats:p>","DOI":"10.1002\/glia.24641","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T03:40:51Z","timestamp":1730864451000},"page":"399-421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Oligodendrocyte Slc48a1 (Hrg1) encodes a functional heme transporter required for myelin integrity"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7385-8310","authenticated-orcid":false,"given":"John H.","family":"Stockley","sequence":"first","affiliation":[{"name":"Wellcome\u2014MRC Cambridge Stem Cell Institute, University of Cambridge  Cambridge UK"},{"name":"Department of Paediatrics Biomedical Campus, University of Cambridge  Cambridge 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