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However, while alterations in microglial morphology and gene expression are observed in human postmortem brain tissue, the mechanisms by which microglia drive and contribute to AD pathology remain ill\u2010defined. Numerous mouse models have been developed to facilitate the disambiguation of the biological mechanisms underlying AD, incorporating amyloidosis, phosphorylated tau, or both. Over time, the use of multiple technologies including bulk tissue and single cell transcriptomics, epigenomics, spatial transcriptomics, proteomics, lipidomics, and metabolomics have shed light on the heterogeneity of microglial phenotypes and molecular patterns altered in AD mouse models. Each of these 'omics\u00a0technologies provide unique information and biological insight. Here, we review the literature on the approaches and findings of these methods and provide a synthesis of the knowledge generated by applying these technologies to mouse models of AD.<\/jats:p>","DOI":"10.1002\/glia.24666","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T06:14:33Z","timestamp":1736144073000},"page":"519-538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Microglial Responses to Alzheimer's Disease Pathology: Insights From \u201cOmics\u201d Studies"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2387-108X","authenticated-orcid":false,"given":"Aquene N.","family":"Reid","sequence":"first","affiliation":[{"name":"Department of Neurology University of Washington School of Medicine  Seattle Washington USA"},{"name":"Department of Laboratory Medicine and Pathology University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3164-9665","authenticated-orcid":false,"given":"Suman","family":"Jayadev","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Washington School of Medicine  Seattle Washington USA"},{"name":"Department of Laboratory Medicine and Pathology University of Washington School of Medicine  Seattle Washington USA"},{"name":"Institute for Stem Cell and Regenerative Medicine University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8615-207X","authenticated-orcid":false,"given":"Katherine E.","family":"Prater","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Washington School of Medicine  Seattle Washington 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