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However, one important but poorly understood element is the necessity of astrocytes in the control of body weight. Here, we apply viral vector\u2010assisted brain\u2010region selective loss of astrocytes to define physiological roles played by astrocytes in the arcuate nucleus of the hypothalamus (ARH) and to elucidate the involved mechanism. We find that astrocyte loss potently augments body weight in adult mice fed chow or high\u2010fat diet. Mechanistically, we find that the loss of astrocytes reduces adipose tissue norepinephrine (NE) contents and chemogenetic stimulation of adipose tissue sympathetic inputs reverses the astrocyte loss\u2010induced increase in body weight. Collectively, our findings in this study suggest a crucial physiological role of astrocytes in preventing diet\u2010induced energy surfeit and obesity by modulating adipose tissue lipid metabolism through central sympathetic outflows to adipose tissues.<\/jats:p>","DOI":"10.1002\/glia.24673","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T01:45:17Z","timestamp":1736387117000},"page":"1068-1076","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Astrocyte Loss Augments Body Weight Through Reduction in Adipose Sympathetic Outflows"],"prefix":"10.1002","volume":"73","author":[{"given":"Dan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Endocrinology Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yale 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