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Recent evidence highlights astrocytes as a potential local source for striatal neuromodulation. There is substantial evidence for norepinephrine\u2010mediated recruitment of cortical astrocyte activity during movement and locomotion. However, it is unclear how astrocytes in the striatum, a region devoid of norepinephrine neuromodulatory inputs, respond during locomotion. Moreover, it remains unknown how dopamine loss affects striatal astrocyte activity and whether astrocyte activity regulates behavioral deficits in PD. We addressed these questions by performing astrocyte\u2010specific calcium recordings and manipulations using in\u00a0vivo fiber photometry and chemogenetics. We find that locomotion elicits astrocyte calcium activity over a slower timescale than neurons. Acute pharmacological blockade of dopamine receptors only moderately reduced locomotion\u2010related astrocyte activity. Yet, unilateral dopamine depletion significantly attenuated astrocyte calcium responses. Chemogenetic stimulation of G\n                    <jats:sub>i<\/jats:sub>\n                    \u2010coupled receptors partially improved this functional astrocyte deficit in dopamine\u2010lesioned mice. In parallel, chemogenetic manipulation restored asymmetrical motor deficits and moderately improved open\u2010field exploratory behavior. Together, our results establish a novel role for functional striatal astrocyte signaling in modulating motor function in PD and highlight non\u2010neuronal targets for potential PD therapeutics.\n                  <\/jats:p>","DOI":"10.1002\/glia.24679","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T07:49:55Z","timestamp":1738655395000},"page":"1188-1202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Chemogenetic Control of Striatal Astrocytes Improves Parkinsonian Motor Deficits in Mice"],"prefix":"10.1002","volume":"73","author":[{"given":"Wesley R.","family":"Evans","sequence":"first","affiliation":[{"name":"WM Keck Center for Collaborative Neuroscience, Department of Cell Biology and Neuroscience Rutgers University  Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sindhuja 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