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Under the experimental conditions, thioridazine causes accumulation of C24 and C26 fatty acids in pup brain lipids, an effect we consider to be a typical consequence of inhibited peroxisomal beta\u2010oxidation. In the corpus callosum of treated pups, the relationship between axon diameter and myelin sheath thickness is altered compared with matched controls. Thioridazine also induces undernourishment effects in 21 day\u2010old rats. Body and brain weight are severely reduced. Liver peroxisomes show a starvation\u2010type metabolism. Undernourishment is known to influence myelination in developing rat brain. However, known consequences of undernourishment, such as decreased myelin concentration in whole brain, decreased percentage of myelinated fibers, and decreased granule\u2010to\u2010Purkinje cell ratio are not present.<\/jats:p>","DOI":"10.1002\/glia.440020407","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T12:10:52Z","timestamp":1104581452000},"page":"260-265","source":"Crossref","is-referenced-by-count":8,"title":["Inhibition of peroxisomal beta\u2010oxidation and brain development in rats"],"prefix":"10.1002","volume":"2","author":[{"given":"Christiane","family":"Van Den Branden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"Dacremont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Hooghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Roels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0736-5748(86)90003-1"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90300-1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901930404"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901930104"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.119.2.178-a"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1981.tb02375.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1051\/rnd:19790205"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90640-0"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1542\/peds.72.3.375","article-title":"The transfer of drugs and other chemicals into human breast milk","volume":"72","author":"Committee on Drugs and American Academy of Pediatrics","year":"1983","journal-title":"Pediatrics"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02531229"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A single method for the isolation and purification of total lipids from animal tissues","volume":"226","author":"Folch J.","year":"1957","journal-title":"J. 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