{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:09:34Z","timestamp":1760170174234},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T00:00:00Z","timestamp":1097539200000},"content-version":"vor","delay-in-days":4059,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Glia"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Theiler's murine encephalomyelitis virus (TMEV) is known to interact with cells of the central nervous system (CNS). Here we report that, interestingly, it is a potent inductor of interleukin\u20106 (IL\u20106) in the CNS of infected animals and in pure cultures of astrocytes. Maximal IL\u20106 gene transcription in glial cells, as detected by bioassay and ELISA, was observed at 6 and 24 h after infection. Astrocytes from both SJL\/J and Balb\/c (strains of mice susceptible and resistant, respectively, to TMEV\u2010induced demyelination) produced similar amounts of IL\u20106, measured in tissue culture supernatants. These results indicate that although an immunomodulatory effect can be exercised by IL\u20106 synthesized by astrocytes, it does not play a crucial role in immune\u2010mediated demyelination induced by TMEV. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/glia.440090106","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:48:24Z","timestamp":1104540504000},"page":"41-47","source":"Crossref","is-referenced-by-count":17,"title":["Interleukin\u20106 production by brain tissue and cultured astrocytes infected with Theiler's murine encephalomyelitis virus"],"prefix":"10.1002","volume":"9","author":[{"given":"Nazario","family":"Rubio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angeles","family":"Sierra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830171004"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830200727"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(90)90104-U"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"984","DOI":"10.4049\/jimmunol.143.3.984","article-title":"Characterization of B lymphocytes present in the demyelinating lesions induced by Theiler's virus","volume":"143","author":"Cash E.","year":"1989","journal-title":"J. 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