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In the adult central nervous system, FABP7, one of the members of this family, is highly expressed in astrocytes and participates in lipid metabolism, regulation of gene expression, and energy homeostasis. Reactive astrocytes in Alzheimer's disease and amyotrophic lateral sclerosis animal models upregulate FABP7 expression. This upregulation may contribute to the pro\u2010inflammatory phenotype that astrocytes display during neurodegeneration and is detrimental for co\u2010cultured neurons. Here, we explore how FABP7 expression modulates astrocyte response to inflammatory stimuli. Our results showed that silencing FABP7 expression in astrocyte cultures before treatment with different inflammatory stimuli decreases the expression of a luciferase reporter expressed under the control of NF\u2010\u03baB \u2010response elements. Correspondingly, FABP7\u2010silenced astrocytes display decreased nuclear translocation of the NF\u2010\u03baB\u2010p65 subunit in response to these stimuli. Moreover, silencing FABP7 decreases the toxicity of stimulated astrocytes toward co\u2010cultured motor neurons. Similar results were obtained after silencing FABP7 in human astrocytes differentiated from induced pluripotent stem cells. Finally, knockdown of astrocytic FABP7 expression in\u00a0vivo reduces glial activation in the cerebral cortex of mice after systemic bacterial lipopolysaccharide (LPS) administration. In addition, whole transcriptome RNA sequencing analysis from the cerebral cortex of LPS\u2010treated mice showed a differential inflammatory transcriptional profile, with attenuation of NF\u2010\u03baB\u2010dependent transcriptional response after FABP7 knockdown. Together, our results highlight the potential of FABP7 as a target to modulate neuroinflammation in the central nervous system.<\/jats:p>","DOI":"10.1002\/glia.70023","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T12:33:53Z","timestamp":1748349233000},"page":"1627-1641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>FABP7<\/scp> Expression Modulates the Response of Astrocytes to Induced Endotoxemia"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4570-3629","authenticated-orcid":false,"given":"Mariana","family":"Bresque","sequence":"first","affiliation":[{"name":"Department of Neurology University of Wisconsin\u2010Madison  Madison Wisconsin 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