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Traditionally considered an autoimmune disease, MS is driven by the immune system's attack on CNS myelin, resulting in cumulative disability. However, conventional anti\u2010inflammatory treatments often fail to prevent progressive deterioration, particularly in the absence of overt inflammation, highlighting the need for a deeper understanding of its pathogenesis. Recent research has revealed a more complex disease mechanism involving both peripheral immune responses and intrinsic CNS factors, with glial cells playing a central role. Persistent inflammation in MS is associated with mixed active\/inactive lesions dominated by microglia and astrocyte dysregulation. These glial populations exhibit maladaptive activation, contributing to failed remyelination and ongoing neurodegeneration. Transcriptomic and epigenomic alterations as well as aging further exacerbate glial dysfunction, creating a self\u2010perpetuating cycle of inflammation and damage. Emerging evidence suggests that the interplay between peripheral immune cells and glial populations and the potential dual\u2010use nature of molecular tools shared by the immune system and CNS disrupts homeostatic signaling, leading to a loss of tissue integrity. This review synthesizes findings on glial cell biology in MS, with a focus on microglia and astrocytes, while addressing their roles in demyelination, synapse loss, and neurodegeneration. The limitations of animal models, particularly EAE, in replicating the complexity of MS are also addressed. Finally, critical questions are outlined to guide future research into glial pathology and to identify novel therapeutic approaches targeting progressive MS.<\/jats:p>","DOI":"10.1002\/glia.70044","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T06:23:33Z","timestamp":1747981413000},"page":"1928-1950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pathways to Progressive Disability in Multiple Sclerosis: The Role of Glial Cells in Chronic <scp>CNS<\/scp> Inflammation"],"prefix":"10.1002","volume":"73","author":[{"given":"Volker","family":"Siffrin","sequence":"first","affiliation":[{"name":"Experimental and Clinical Research Center, Max\u2010Delbr\u00fcck\u2010Center for Molecular Medicine and Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Department of Neurology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie 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