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Astrocytes are an important component in scar formation, crucial for suppression of injury propagation, effective wound healing, and the regulation of neuronal plasticity. Here, we identify the role of the actin\u2010binding protein Drebrin (DBN) in reactive astrogliosis following SCI. SCI induces the upregulation of DBN in astrocytes, which controls immediate injury containment but also the long\u2010term preservation of tissue integrity and healing in the spinal cord. DBN knockout results in enlarged spinal cord lesions, increased immune cell infiltration, and neurodegeneration. Mechanistically, DBN loss disrupts the polarization of scar border\u2010forming astrocytes, leading to impaired encapsulation of the injury. In summary, DBN serves as a pivotal regulator of SCI outcome by modulating astrocytic polarity, which is essential for establishing a protective barrier confining the lesion site.<\/jats:p>","DOI":"10.1002\/glia.70048","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:26:07Z","timestamp":1749727567000},"page":"1910-1924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Drebrin Upregulation Regulates Astrocyte Polarization and Supports Tissue Recovery After Spinal Cord Injury in Mice"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4812-9458","authenticated-orcid":false,"given":"Barbora","family":"Smejkalov\u00e1","sequence":"first","affiliation":[{"name":"Institute of Experimental Medicine, Czech Academy of Sciences  Prague Czech Republic"},{"name":"Second Faculty of Medicine Charles University  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4376-4369","authenticated-orcid":false,"given":"Marta","family":"Ornaghi","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2784-8434","authenticated-orcid":false,"given":"Kate\u0159ina","family":"\u0160t\u011bp\u00e1nkov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine, Czech Academy of Sciences  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9319-899X","authenticated-orcid":false,"given":"Juliane","family":"Schiweck","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7622-5837","authenticated-orcid":false,"given":"Lucia","family":"Machov\u00e1 Urdz\u00edkov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine, Czech Academy of Sciences  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4602-8143","authenticated-orcid":false,"given":"Robert","family":"Huelse","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5053-2211","authenticated-orcid":false,"given":"Susanne","family":"Mueller","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, Charit\u00e9 Core Facility Experimental MRIs  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8777-4823","authenticated-orcid":false,"given":"Philipp","family":"Boehm\u2010Sturm","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, Charit\u00e9 Core Facility Experimental MRIs  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9798-9083","authenticated-orcid":false,"given":"Jessica C. 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