{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:27:42Z","timestamp":1779931662672,"version":"3.53.1"},"reference-count":104,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["S10OD028600"],"award-info":[{"award-number":["S10OD028600"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS110627"],"award-info":[{"award-number":["R01NS110627"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS134493"],"award-info":[{"award-number":["R01NS134493"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R03AG089077"],"award-info":[{"award-number":["R03AG089077"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["1R01HD114827\u201001A1"],"award-info":[{"award-number":["1R01HD114827\u201001A1"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["2R01HD097331\u201006A1"],"award-info":[{"award-number":["2R01HD097331\u201006A1"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01DC017149"],"award-info":[{"award-number":["R01DC017149"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Olfactory Ensheathing Cells (OECs) are glial cells originating from the neural crest and are critical for bundling olfactory axons to the brain. Their development is crucial for the migration of Gonadotropin\u2010Releasing Hormone\u20101 (GnRH\u20101) neurons, which are essential for puberty and fertility. OECs have garnered interest as potential therapeutic targets for central nervous system lesions, although their development is not fully understood. Our single\u2010cell RNA sequencing of mouse embryonic nasal tissues suggests that OECs and Schwann cells share a common origin from Schwann cell precursors yet exhibit significant genetic differences. The transcription factors Yap and Taz have previously been shown to play a crucial role in Schwann cell development. We used\n                    <jats:italic>Sox10<\/jats:italic>\n                    \u2010Cre mice to conditionally ablate\n                    <jats:italic>Yap<\/jats:italic>\n                    and\n                    <jats:italic>Taz<\/jats:italic>\n                    in the migrating neural crest and its derivatives. Our analyses showed reduced Sox10+ glial cells along nerves in the nasal region, altered gene expression in Schwann cells (SCs), melanocytes, and OECs, and a significant reduction in olfactory sensory neurons and vascularization in the vomeronasal organ. However, despite these changes, GnRH\u20101 neuronal migration remained unaffected. Our findings highlight the importance of the Hippo pathway in OEC development and how changes in cranial neural crest derivatives indirectly impact the development of olfactory epithelia.\n                  <\/jats:p>","DOI":"10.1002\/glia.70057","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T12:09:55Z","timestamp":1752062995000},"page":"2077-2097","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Shared Lineage, Distinct Outcomes: Yap and Taz Loss Differentially Impact Schwann and Olfactory Ensheathing Cell Development Without Disrupting\n                    <scp>GnRH<\/scp>\n                    \u20101 Migration"],"prefix":"10.1002","volume":"73","author":[{"given":"Ed Zandro M.","family":"Taroc","sequence":"first","affiliation":[{"name":"Department of Biological Sciences The Center for Neuroscience Research, the RNA Institute, University at Albany, State University of New York  Albany New York USA"},{"name":"National Institute of Dental and Craniofacial Research, Intramural Research Program, Neural Crest Development and Disease Unit, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Enrico","family":"Amato","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences The Center for Neuroscience Research, the RNA Institute, University at Albany, State University of New York  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis M.","family":"Semon","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences The Center for Neuroscience Research, the RNA Institute, University at Albany, State University of New York  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikki","family":"Dolphin","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences The Center for Neuroscience Research, the RNA Institute, University at Albany, State University of New York  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Briane","family":"Beck","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Experimental Therapeutics Albany Medical College  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Belin","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Experimental Therapeutics Albany Medical College  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Poitelon","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Experimental Therapeutics Albany Medical College  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6547-3464","authenticated-orcid":false,"given":"Paolo E.","family":"Forni","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences The Center for Neuroscience Research, the RNA Institute, University at Albany, State University of New York  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.32041"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.25599"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0012\u20101606(03)00161\u20101"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4541"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306\u20104522(82)90231\u20107"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1012248107"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.20135249"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00347"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010020\u20100591\u20103"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.186601"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.8.1611"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490290206"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9010151"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012\u20101606(85)90101\u20100"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0960\u20109822(07)00562\u20103"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.b.10014"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15161"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.263451"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092100214"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2022.02.017"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012\u20101606(80)90062\u20107"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3238\u201013.2013"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6087\u201010.2011"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2014.09.004"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0896\u20106273(00)00080\u20105"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.11.06.622365"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.09.021"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456\u2010021\u201009791\u20109"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.20982"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.50138"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.10.023"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21030"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv497"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010023\u201001767\u2010y"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8050502"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.97356"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.9.2730"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24467"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0012\u20101606(03)00247\u20101"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.176238"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u2010444\u201063855\u20107.00008\u20103"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.186924"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047794"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41540\u2010024\u201000414\u20109"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23949"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1746"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00069"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021108780"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756\u20106606\u20104\u201034"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010021\u201003829\u20103"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0085\u201016.2016"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3178\u201007.2007"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00398"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/ntls.20210037"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt703"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00121-5"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2013.04.026"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.77259"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2018.06.007"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0123278"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368910X492634"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2467"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.01.041"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.10.061"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.179069"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03837"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20395"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.2.399"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ctdb.2014.11.001"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0867\u201010.2010"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041089"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.184036"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23870"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.03.024"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0298\u2010171"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4316"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/35072576"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18\u201010\u201003803.1998"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003380"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23515"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20041"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12131795"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8050411"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00344-8"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00336"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24566"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aas9536"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2022111955"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.64773"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.601923"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00070"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1977\u201019.2019"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.029074"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjy049"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202212_30479"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.888601"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh029"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126920"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578\u2010022\u201000765\u2010y"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1159\/000079742"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.20.8132"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1900038116"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2008.01.006"},{"issue":"9","key":"e_1_2_9_105_1","first-page":"838","article-title":"Kallmann Syndrome With Deafness Caused by SOX10 Mutation: Advances in Research","volume":"23","author":"Zhou X.","year":"2017","journal-title":"Zhonghua Nan Ke Xue"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.70057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T06:09:24Z","timestamp":1754719764000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.70057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,9]]},"references-count":104,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/glia.70057"],"URL":"https:\/\/doi.org\/10.1002\/glia.70057","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.02.13.638196","asserted-by":"object"}]},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,9]]},"assertion":[{"value":"2025-02-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}