{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:58:33Z","timestamp":1792429113886,"version":"4.5.0"},"reference-count":150,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG052371"],"award-info":[{"award-number":["AG052371"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG064465"],"award-info":[{"award-number":["AG064465"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG083268"],"award-info":[{"award-number":["AG083268"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA055781"],"award-info":[{"award-number":["DA055781"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH016880"],"award-info":[{"award-number":["MH016880"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS086933"],"award-info":[{"award-number":["NS086933"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020341","name":"Linda Crnic Institute for Down Syndrome, University of Colorado School of Medicine, Anschutz Medical Campus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A greater understanding of the neurobiology of nicotine is needed to reduce or prevent chronic addiction, ameliorate detrimental nicotine withdrawal effects, and improve cessation rates. Nicotine binds and activates two astrocyte\u2010expressed nicotinic acetylcholine receptors (nAChRs), \u03b14\u03b22 and \u03b17. Protein kinase B\u2010\u03b2 (Pkb\u2010\u03b2 or Akt2) expression is restricted to astrocytes in mice and humans and is activated by nicotine. To determine if AKT2 plays a role in astrocytic nicotinic responses, we generated astrocyte\u2010specific Akt2 conditional knockout (cKO) and full Akt2 KO mice. For in\/ex vivo studies, we examined mice exposed to chronic nicotine for 2\u2009weeks in drinking water (200\u2009\u03bcg\/mL) or following acute nicotine challenge (0.09, 0.2\u2009mg\/kg) after 24\u2009h. Our in\u00a0vitro studies used cultured mouse astrocytes to measure nicotine\u2010dependent astrocytic responses. Sholl analysis was used to measure glial fibrillary acidic protein responses in astrocytes. Our data show wild\u2010type (WT) mice exhibit increased astrocyte morphological complexity during acute nicotine exposure, with decreasing complexity during chronic nicotine use, whereas Akt2 cKO mice showed enhanced acute responses and reduced area following chronic exposure. In culture, we found 100\u2009\u03bcM nicotine sufficient for morphological changes and blocking \u03b17 or \u03b14\u03b22 nAChRs prevented observed morphological changes. We performed conditioned place preference (CPP) in Akt2 cKO mice, which revealed reduced nicotine preference in cKO mice compared to controls. Finally, we performed RNASeq comparing nicotine\u2010 and LPS\u2010mediated gene expression, identifying robust differences between these two astrocytic stimuli. These findings show the importance of nAChRs and AKT2 signaling in the astrocytic response to nicotine.<\/jats:p>","DOI":"10.1002\/glia.70059","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T17:14:56Z","timestamp":1752599696000},"page":"2098-2129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>AKT2<\/scp>\n                    Modulates Astrocytic Nicotine Responses In\u00a0Vivo"],"prefix":"10.1002","volume":"73","author":[{"given":"Andrew M.","family":"Lombardi","sequence":"first","affiliation":[{"name":"Department of Integrative Physiology University of Colorado  Boulder Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Griffioen","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology University of Colorado  Boulder Colorado USA"},{"name":"Institute for Behavioral Genetics University of Colorado  Boulder Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Wong","sequence":"additional","affiliation":[{"name":"Institute for Behavioral Genetics University of Colorado  Boulder Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3333-853X","authenticated-orcid":false,"given":"Ryan","family":"Milstead","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology University of Colorado  Boulder Colorado USA"},{"name":"Institute for Behavioral Genetics University of Colorado  Boulder Colorado USA"},{"name":"Linda Crnic Institute Anschutz Medical Center  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6646-9511","authenticated-orcid":false,"given":"Curtis","family":"Borski","sequence":"additional","affiliation":[{"name":"Institute for Behavioral Genetics University of Colorado  Boulder Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Shiely","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology University of Colorado  Boulder Colorado USA"},{"name":"Institute for Behavioral Genetics University of Colorado  Boulder Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myra E.","family":"Bower","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology University of Colorado  Boulder Colorado USA"},{"name":"Institute for Behavioral Genetics University of Colorado  Boulder Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology University of Colorado  Boulder Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"LaPlante","sequence":"additional","affiliation":[{"name":"Institute for Behavioral Genetics University of Colorado  Boulder Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa A.","family":"Ehringer","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology University of Colorado  Boulder Colorado USA"},{"name":"Institute for Behavioral Genetics University of Colorado  Boulder Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Stitzel","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology University of Colorado  Boulder Colorado USA"},{"name":"Institute for Behavioral Genetics University of Colorado  Boulder Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2036-0201","authenticated-orcid":false,"given":"Charles A.","family":"Hoeffer","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology University of Colorado  Boulder Colorado USA"},{"name":"Institute for Behavioral Genetics University of Colorado  Boulder Colorado USA"},{"name":"Linda Crnic Institute Anschutz Medical Center  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107190"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218028"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00233"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22\u201007\u201002443.2002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010001\u20100961\u20106"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24011"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.04.034"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156952"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2023.09.006"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.10.013"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201014198\u20108"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/02698811211005629"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102105\u201014\u2010128"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty560"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.292.5522.1728"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4103\u201008.2009"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8060586"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010005\u20100047\u2010y"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010006\u20100624\u20108"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2853\u201005.2005"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.01.005"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10296"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.11.009"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/1044\u20107431(92)90043\u20102"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.731603"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010020\u201000783\u20104"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgg.2024.08.009"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.1036"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304\u20103940(00)01076\u20104"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10943"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10942"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36710"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.16109"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010004\u20102007\u20103"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3872"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.32607\/20758251-2015-7-2-42-47"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2006.12.005"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51851"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920\u2010018\u20100873\u20103"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010021\u201000905\u20106"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201025846\u20102"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22826"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2009.11.003"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201043021\u20108"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11050520"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071649"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6544a2"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23897"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010019\u20100218\u20101"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149120"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11091361"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008035200"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.1030807"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.10.040"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw377"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-8488-1_4"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1037\/bne0000029"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2015.11.021"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/2051\u20105960\u20101\u201034"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.30640"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/texcom\/tgab036"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163\u20101047(90)90509\u20105"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.08.048"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2015.03.001"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00218.2019"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21029"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1515\/tnsci\u20102019\u20100041"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S159146"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742\u20102094\u20109\u201098"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2012.08.009"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010014\u20100550\u20108"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112674"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8020184"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0095"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1080\/14622200110073380"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460\u20109568.2003.02564.x"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010018\u20105139\u20106"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010006\u20100441\u20100"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2023.1173200"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263\u2010014\u20100142\u2010x"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388\u2010023\u201002875\u20104"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000204984.21748.e3"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.12.044"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.31011"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2019.172836"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22930"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0306\u20104522(02)00041\u20106"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20398"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00183.2013"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2001.01359.x"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010017\u20100967\u20106"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010003\u20101692\u20107"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2009.07.020"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2007.03.003"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03402177"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20207"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2013"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2009.05.001"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1183844"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207458308986121"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0091\u20103057(00)00235\u20105"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.8b00391"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13040692"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010016\u20100725\u20101"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.20133913"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2023.137167"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2005.02.002"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010018\u20100325\u20108"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005477\u20104"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.3791\/50079"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.071540198"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.1984.tb12739.x"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204610200"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106143"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1717\u201008.2008"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15789"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2009.08.002"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020420"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16065"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-07011-6"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2010.04.014"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085591"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22657"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010022\u201003237\u20108"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10132"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi072"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201042751\u2010z"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u2010981\u201013\u20109913\u20108_3"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424\u2010019\u201002310\u20102"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2015.09.003"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2006.05187.x"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI16147"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2014.04.007"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010015\u20101499\u20108"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.56630"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2016.03.005"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401\u2010019\u20100299\u20104"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.90"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102296"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300393"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666170714092436"},{"key":"e_1_2_10_146_1","doi-asserted-by":"crossref","unstructured":"Zeisel A. A. B.Mu\u00f1oz\u2010Manchado S.Codeluppi et\u00a0al.2015.\u201cBrain Structure. Cell Types in the Mouse Cortex and Hippocampus Revealed by Single\u2010Cell RNA\u2010Seq.\u201d","DOI":"10.1126\/science.aaa1934"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2017.01.004"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.3892\/or_00000829"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010021\u201000949\u20108"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9605265"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13013"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.70059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T06:09:27Z","timestamp":1754719767000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.70059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":150,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/glia.70059"],"URL":"https:\/\/doi.org\/10.1002\/glia.70059","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.05.31.596856","asserted-by":"object"}]},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,15]]},"assertion":[{"value":"2024-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}