{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T23:03:41Z","timestamp":1791673421918,"version":"4.3.4"},"reference-count":137,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS119243"],"award-info":[{"award-number":["NS119243"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS122782"],"award-info":[{"award-number":["NS122782"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Microglia are the resident immune cells of the CNS. Under homeostatic conditions, microglia play critical roles in orchestrating synaptic pruning, debris clearance, and dead cell removal. In disease, they are powerful mediators of neuroinflammation, as they rapidly respond to injury or infection within the CNS by altering their morphology, proliferating, and releasing cytokines and other signaling molecules. Understanding the molecular pathways involved in microglial function is pivotal for advancing neurobiological research and developing effective strategies for CNS disorders. In this context, P2RY12 is a G protein\u2010coupled receptor (GPCR) that is uniquely enriched in microglia in the parenchyma and a canonical marker of homeostatic, ramified microglia. However, P2RY12 is downregulated in activated microglia and in neurological conditions. The consequences of P2RY12 downregulation in disease\u2010associated microglia and how they influence microglial activation remain poorly understood. In this study, we apply transcriptional and histological methods to explore the changes to microglia upon a genetic P2RY12 loss. Our findings reveal that P2RY12\u2010deficient microglia experience alterations in distinct metabolic pathways while preserving overall homeostatic microglial transcriptional identity. Lack of P2RY12 alters signature genes involved in homeostatic iron metabolism. Importantly, the genes encoding proteins in the Glutathione Peroxidase 4 (\n                    <jats:italic>Gpx4<\/jats:italic>\n                    )\u2010Glutathione (GSH) antioxidant pathway related to ferroptosis susceptibility are impaired upon microglial activation with lipopolysaccharide (LPS) treatment. These results highlight the critical role of P2RY12 in regulating microglial immune and metabolic transcriptional responses under both homeostatic and inflammatory conditions, providing insights into its involvement in CNS pathophysiology.\n                  <\/jats:p>","DOI":"10.1002\/glia.70078","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T08:39:14Z","timestamp":1755247154000},"page":"2464-2482","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Transcriptional Regulation of Microglial Metabolic and Activation States by\n                    <scp>P2RY12<\/scp>"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6327-3071","authenticated-orcid":false,"given":"Aida Oryza","family":"Lopez\u2010Ortiz","sequence":"first","affiliation":[{"name":"Department of Neuroscience University of Virginia School of Medicine  Charlottesville Virginia USA"},{"name":"Center for Brain Immunology and Glia University of Virginia  Charlottesville Virginia USA"},{"name":"Neuroscience Graduate Program University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Doceti","sequence":"additional","affiliation":[{"name":"Center for Brain Immunology and Glia University of Virginia  Charlottesville Virginia USA"},{"name":"Department of Microbiology, Immunology and Cancer University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JaQuinta","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8452-9795","authenticated-orcid":false,"given":"Abigayle","family":"Duffy","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Virginia School of Medicine  Charlottesville Virginia USA"},{"name":"Center for Brain Immunology and Glia University of Virginia  Charlottesville Virginia USA"},{"name":"Neuroscience Graduate Program University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Coburn","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Virginia School of Medicine  Charlottesville Virginia USA"},{"name":"Center for Brain Immunology and Glia University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhabue","family":"K. Okojie","sequence":"additional","affiliation":[{"name":"Center for Brain Immunology and Glia University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Aidita","family":"Sou","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4175-6053","authenticated-orcid":false,"given":"Alban","family":"Gaultier","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Virginia School of Medicine  Charlottesville Virginia USA"},{"name":"Center for Brain Immunology and Glia University of Virginia  Charlottesville Virginia USA"},{"name":"Neuroscience Graduate Program University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1294-475X","authenticated-orcid":false,"given":"Ukpong B.","family":"Eyo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Virginia School of Medicine  Charlottesville Virginia USA"},{"name":"Center for Brain Immunology and Glia University of Virginia  Charlottesville Virginia USA"},{"name":"Neuroscience Graduate Program University of Virginia  Charlottesville Virginia USA"},{"name":"Department of Microbiology, Immunology and Cancer University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-7-13"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00448F"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2777-8"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.ade7652"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24101"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.05.014"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.08.008"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201025590\u20108"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2005.04779.x"},{"issue":"4","key":"e_1_2_9_11_1","first-page":"544","article-title":"Identification of Novel Glutathione Transferases and Polymorphic Variants by Expressed Sequence Tag Database Analysis","volume":"29","author":"Board P.","year":"2001","journal-title":"Drug Metabolism and Disposition"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.04.043"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-022-01519-7"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph11040120"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-022-00531-1"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-023-08736-3"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080130"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-28753-4_4922"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","unstructured":"Cordoba C. M. M.Barrera S.Perdomo et\u00a0al.2021.\u201cInhibitor of Lysyl Oxidase in the Optic Nerve Head Complex Imparts Partial Protection Against Injury in Experimental Glaucoma.\u201d","DOI":"10.21203\/rs.3.rs-968649\/v1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.02.028"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180247"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20211071"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068667"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.05.003"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00769-0"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201800753RR"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0993-19.2019"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-024-01060-w"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0416-14.2014"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02118"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201056093\u20105"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-376202"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.380535"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2960-3"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz931"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.11.010"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1194637"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020537"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600259"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041636"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal3222"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.08.001"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601979"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1997"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.07.002"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-022-00552-w"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1805"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3554"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b6bb95"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad356"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85898-9"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14344"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-32798-9"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105684"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.018"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00011.2010"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2016.164"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.39.1.267"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1006\/niox.2000.0280"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.04.050"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102105\u20109\u2010559"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.9.5596"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.11.018"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.35.040195.003223"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.199"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251326267"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117435"},{"key":"e_1_2_9_70_1","first-page":"1","article-title":"Ferroptosis\u2010Related Gene Signatures in Epilepsy: Diagnostic and Immune Insights","volume":"62","author":"Li X.","year":"2024","journal-title":"Molecular Neurobiology"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-023-00691-8"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.065458"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1415518111"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1398-3"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-022-00943-y"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI178628"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00215"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20678"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1441338"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01022-8"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.14806\/ej.17.1.200"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0924-x"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1500937112"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23097"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076334"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.5.2216"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000080"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-19-07526.2001"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13601-8"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M108382200"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3407"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2114326118"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1202529"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.10.020"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-019-0492-x"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524014666141203095503"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.38"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1032"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.17"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-018-0254-8"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132528"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-017-9587-0"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-020-0565-1"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42096-7"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4397"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.615031"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.09.014"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986709787846578"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.08.014"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041366"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-025-02295-1"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3898"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR-D-24-00284"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.08.009"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.021"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2024.100911"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4158-11.2011"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23961"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010019\u20100850\u2010z"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1481-5"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.05.048"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21020678"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz2288"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107496"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-022-09848-4"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04775-z"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113598"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30033"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.669798"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-02277-7"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl5723"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi052443r"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1280639"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-024-00711-9"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx113"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.70078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:15:58Z","timestamp":1761128158000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.70078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,15]]},"references-count":137,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/glia.70078"],"URL":"https:\/\/doi.org\/10.1002\/glia.70078","archive":["Portico"],"relation":{},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,15]]},"assertion":[{"value":"2025-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}