{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:08:31Z","timestamp":1791288511227,"version":"4.3.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2001675"],"award-info":[{"award-number":["2001675"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by the degeneration of motor neurons. However, the surrounding glia, including oligodendrocytes, also exhibit ALS pathology and TDP\u201043 related dysfunction. Given that oligodendrocytes, the myelinating cells of the central nervous system, are essential for motor neuron function, they may play an underappreciated role in ALS. Here, we have extensively characterized the oligodendrocyte lineage and myelin integrity in the TDP\u201043\n                    <jats:sup>Q331K<\/jats:sup>\n                    mouse model of ALS. In the lumbar spinal cord of end\u2010stage male TDP\u201043\n                    <jats:sup>Q331K<\/jats:sup>\n                    mice (TDP\u201043), compared to wild\u2010type littermates (WT), oligodendrocyte precursor cell (OPC) density, oligodendrocyte proliferation, and differentiation were all increased. There was no correlative increase in the density of mature oligodendrocytes, which was determined to be due to an increase in oligodendroglial apoptosis. In end\u2010stage mice, myelin reflectance was increased in the dorsal column of TDP\u201043 mice, while electron microscopy showed myelin damage and misfolding in the TDP\u201043 mice. Our data suggest that the oligodendrocyte lineage is impacted in TDP\u201043 related ALS.\n                  <\/jats:p>","DOI":"10.1002\/glia.70090","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:25:13Z","timestamp":1760095513000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oligodendroglial Densities and Myelin Structure Are Altered in\n                    <scp>TDP<\/scp>\n                    \u201043 Related Amyotrophic Lateral Sclerosis"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2244-1803","authenticated-orcid":false,"given":"Katherine N.","family":"Lewis","sequence":"first","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3104-210X","authenticated-orcid":false,"given":"Georgina A.","family":"Craig","sequence":"additional","affiliation":[{"name":"Li Ka Shing Knowledge Institute, Unity Health, St Michael's Hospital  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Mason","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Tomas","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Cuic","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam K.","family":"Walker","sequence":"additional","affiliation":[{"name":"Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute  Brisbane Australia"},{"name":"Sydney Pharmacy School, Faculty of Medicine and Health The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Gonsalvez","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Developmental Biology Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"Turner","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha K.","family":"Barton","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30199-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1222809110"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.01.052"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00124"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.705306"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab255"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.20517\/2347-8659.2017.47"},{"issue":"1","key":"e_1_2_10_9_1","article-title":"The Respiratory Phenotype of Rodent Models of Amyotrophic Lateral Sclerosis and Spinocerebellar Ataxia","volume":"3","author":"Fusco A. 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