{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:47:27Z","timestamp":1787068047265,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2020\/39\/D\/NZ3\/03070"],"award-info":[{"award-number":["2020\/39\/D\/NZ3\/03070"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2024\/53\/B\/NZ4\/03058"],"award-info":[{"award-number":["2024\/53\/B\/NZ4\/03058"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Astrocytes differentiate and mature during postnatal development, but the molecular mechanisms linking their maturation to neuronal function remain unclear. We investigated the role of Wnt\/\u03b2\u2010catenin signaling and its effector, the transcription factor TCF7L2, in postnatal astrocytes using single\u2010nucleus RNA sequencing, imaging, morphometric analysis, microdialysis, and electrophysiology in\n                    <jats:italic>Tcf7l2<\/jats:italic>\n                    conditional knockout (cKO) mice. Loss of\n                    <jats:italic>Tcf7l2<\/jats:italic>\n                    caused widespread transcriptional dysregulation in astrocytes, particularly in genes related to amino acid and ion transport, as well as membrane potential regulation. These mice showed disrupted amino acid homeostasis, astrocyte swelling, and impaired extracellular potassium clearance in the somatosensory cortex. These astrocytic changes were accompanied by altered gene expression in cortical pyramidal neurons, reduced excitability, and a hyperpolarized resting membrane potential. Our results suggest that astrocytic TCF7L2 is crucial in coordinating ion and amino acid transport in adulthood, thereby contributing to maintaining extracellular homeostasis and supporting neuronal function. This study identifies TCF7L2 as a key regulator of astrocyte\u2010mediated neurophysiological support and underscores the importance of its role in astrocyte maturation during postnatal development.\n                  <\/jats:p>","DOI":"10.1002\/glia.70103","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:47:15Z","timestamp":1765007235000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Astrocytic\n                    <scp>TCF7L2<\/scp>\n                    Impacts Brain Osmoregulation and\u00a0Restricts Neuronal Excitability"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4394-3394","authenticated-orcid":false,"given":"Mariusz","family":"Popek","sequence":"first","affiliation":[{"name":"Department of Neurotoxicology Mossakowski Medical Research Institute, Polish Academy of Sciences  Warsaw 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