{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:03:37Z","timestamp":1792033417524,"version":"4.4.0"},"reference-count":90,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS38878"],"award-info":[{"award-number":["NS38878"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS074256"],"award-info":[{"award-number":["NS074256"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG046929"],"award-info":[{"award-number":["AG046929"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Oligodendrocytes (OLs) generate myelin sheaths around axons and maintain them to facilitate the propagation of action potentials and support neuronal metabolism and synaptic function. Previously, we have shown that Fibroblast Growth Factor Receptor\u20101 and \u20102 (FGFR1\/2) signaling is required for oligodendrocyte precursor cell (OPC) expansion, promoting myelin growth during developmental myelination and maintaining myelin\/axonal integrity in the spinal cord during adulthood. However, whether OL\u2010lineage cells may affect neuronal synaptic functions and impact memory\/learning during adulthood\/aging remained largely unknown. Here, we showed that FGFR1\/2 signaling in OPCs and OLs is required throughout adulthood and is critical for the long\u2010term maintenance of synaptic activity and memory. Specifically, the lack of FGFR1\/2 signaling within OL\u2010lineage cells resulted in the impairment of long\u2010term potentiation (LTP), a reduction in docked synaptic vesicles at the synaptic terminals, deficits in hippocampal\u2010based memory and learning, and \u03b2\u2010APP accumulation in older animals. Importantly, we found that there was no loss of OPCs or OLs, myelin degeneration, astrogliosis, microglial activation, or reduction in myelin thickness in the adult hippocampus of mutant mice. Furthermore, the tamoxifen\u2010inducible loss of FGFR1\/2 signaling during adulthood also impaired LTP. In addition, the conditional ablation of either FGFR1 or FGFR2 individually in the OL\u2010lineage cells impaired LTP during adulthood, although at different levels. Thus, these observations bring up the possibility that FGFR1\/2 signaling in OL\u2010lineage cells may play a potentially novel, previously unrecognized role in OL\u2010neuron communication for the maintenance of synaptic plasticity and memory functions in the normal adult\/aging brain.<\/jats:p>","DOI":"10.1002\/glia.70123","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T12:11:06Z","timestamp":1765195866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>FGF<\/scp>\n                    Receptor Signaling in Oligodendrocytes Regulates Synaptic Plasticity, Learning, and Memory in the Adult Brain"],"prefix":"10.1002","volume":"74","author":[{"given":"M.","family":"Furusho","sequence":"first","affiliation":[{"name":"Department of Neuroscience University of Connecticut Medical School  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Connecticut Medical School  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7195-7617","authenticated-orcid":false,"given":"R.","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Connecticut Medical School  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Connecticut Medical School  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5103-3860","authenticated-orcid":false,"given":"A.","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Connecticut Medical School  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2015.11.006"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy229"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.68051960.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0731090.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-21-07737.2003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90010-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/35012083"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0519194"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.207"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20818"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.05.012"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.74"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1788"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470119055"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.056"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06120-6"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.100087"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/gene.10154"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200312012"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.04.031"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-023-02837-5"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12242"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2120-05.2005"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23629"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000621"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5615-08.2009"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6005-11.2012"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3316-16.2017"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23743"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4800-10.2011"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22838"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2017-0011"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1360-10.2010"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0113-1"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.11.005"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171831"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0121-5"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04722-0"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4403-12.2013"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3360-14.2014"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0299-16.2016"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23602"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0137-12.2012"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2005.02.014"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.42156"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.40033"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1444-16.2016"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001366RR"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3573-06.2006"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.10.004"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1102349108"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33200-4"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1095"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-7431(03)00029-0"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3263"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00904"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1220845"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22121"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02719-2"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-080317-061853"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1984.tb06702.x"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.30.051606.094309"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00751-9"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-024-01642-2"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2017.09.013"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001993"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.028"},{"key":"e_1_2_10_69_1","first-page":"30","article-title":"Characterization of Myelin Pathology in the Hippocampal Complex of a Transgenic Mouse Model of Alzheimer's Disease","volume":"10","author":"Schmued L. C.","year":"2013","journal-title":"Current Alzheimer Research"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03052-4"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.11.006"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2018"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.10.013"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.03.013"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1105681"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.16262"},{"key":"e_1_2_10_77_1","unstructured":"Tognatta R.2012.CNP\u2010Expressing Progenitors Display Strikingly Differential Oligodendroglial or Multipotent Fates as Assessed by Two Cre Reporter Lines PhD Thesis of the Mathematisch\u2010Naturwissenschaftlichen Fakult\u00e4t der Universit\u00e4t Bonn Germany Dept. Neurosurgery."},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23095"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199801293380502"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.250703"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07082.x"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101767"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2007.00729.x"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4351"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-020-00379-8"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.04.094"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1740925X08000070"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0866-19.2019"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1860-14.2014"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3281ac212e"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.759477"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.70123","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/glia.70123","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.70123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T13:57:30Z","timestamp":1776434250000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.70123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,8]]},"references-count":90,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/glia.70123"],"URL":"https:\/\/doi.org\/10.1002\/glia.70123","archive":["Portico"],"relation":{},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,8]]},"assertion":[{"value":"2025-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70123"}}