{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:06:52Z","timestamp":1784293612717,"version":"3.55.0"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000261","name":"Multiple Sclerosis Society of Canada","doi-asserted-by":"publisher","award":["920566"],"award-info":[{"award-number":["920566"]}],"id":[{"id":"10.13039\/501100000261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000261","name":"Multiple Sclerosis Society of Canada","doi-asserted-by":"publisher","award":["2362"],"award-info":[{"award-number":["2362"]}],"id":[{"id":"10.13039\/501100000261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT \u2010 183666"],"award-info":[{"award-number":["PJT \u2010 183666"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Multiple sclerosis (MS) affects women more frequently than men, but the disease progresses more aggressively in men. We have demonstrated that acute intermittent hypoxia (AIH), a noninvasive therapy, promotes repair and remyelination and alters disease course in the female MOG\n                    <jats:sub>35\u201055<\/jats:sub>\n                    experimental autoimmune encephalomyelitis (EAE) mouse model of MS. Given the importance of understanding sex\u2010specific responses to potential MS therapies, we investigated whether AIH exerts similar therapeutic effects in male EAE mice. EAE was induced by MOG\n                    <jats:sub>35\u201055<\/jats:sub>\n                    immunization in C57BL\/6 male mice. Male EAE mice received either AIH (10\u2009cycles\u20105\u2009min 11% oxygen alternating with 5\u2009min 21% oxygen) or Normoxia (21% oxygen for same duration) once daily for 7d beginning at near peak EAE disease clinical score of 2.5. Mice were followed post\u2010last treatment for an additional 7d or 14d before assessing histopathology. Clinical scores, inflammation, myelination, and neurorepair were evaluated. Compared to Normoxia, AIH significantly improved clinical scores in male EAE mice with mice exhibiting reduced inflammation and increased myelination\/remyelination within inflamed regions. Further, AIH polarized remaining immune cells toward a pro\u2010repair phenotype, promoted OPC recruitment to demyelinated regions, and increased the presence of mature, myelinating oligodendrocytes, and myelination. An axon protective phenotype was also significantly improved with AIH, supporting enhanced neuroprotection. Our findings reveal that AIH has comparable, albeit slightly less robust beneficial therapeutic effects in male as was previously shown in female EAE mice. Altogether, this study highlights the potential of AIH as a therapy for MS, capable of addressing the disease's differential impacts in both sexes.\n                  <\/jats:p>","DOI":"10.1002\/glia.70127","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T01:41:30Z","timestamp":1766972490000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute Intermittent Hypoxia Exerts Beneficial Effects and Promotes Repair in Male Mice in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis"],"prefix":"10.1002","volume":"74","author":[{"given":"Nataliya","family":"Tokarska","sequence":"first","affiliation":[{"name":"Department of Anatomy, Physiology and Pharmacology University of Saskatchewan  Saskatoon Saskatchewan Canada"},{"name":"Cameco MS Neuroscience Research Centre, University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology and Pharmacology University of Saskatchewan  Saskatoon Saskatchewan Canada"},{"name":"Cameco MS Neuroscience Research Centre, University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer Rathnayaka","family":"Koralage","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology and Pharmacology University of Saskatchewan  Saskatoon Saskatchewan Canada"},{"name":"Cameco MS Neuroscience Research Centre, University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin M. A.","family":"Naniong","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology and Pharmacology University of Saskatchewan  Saskatoon Saskatchewan Canada"},{"name":"Cameco MS Neuroscience Research Centre, University of Saskatchewan  Saskatoon Saskatchewan Canada"},{"name":"Integrated Program in Neurosciences McGill University &amp; Montreal Clinical Research Institute  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayne M.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology and Pharmacology University of Saskatchewan  Saskatoon Saskatchewan Canada"},{"name":"Cameco MS Neuroscience Research Centre, University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology and Pharmacology University of Saskatchewan  Saskatoon Saskatchewan Canada"},{"name":"Cameco MS Neuroscience Research Centre, University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6648-3242","authenticated-orcid":false,"given":"Valerie M. 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