{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:22:26Z","timestamp":1792041746182,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["NRF\u20102022R1A2C2009817"],"award-info":[{"award-number":["NRF\u20102022R1A2C2009817"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Yes\u2010associated protein (YAP) and transcriptional coactivator with PDZ\u2010binding motif (TAZ), core effectors of the Hippo pathway, are emerging as mechanosensitive regulators of inflammation and tissue repair. However, their roles in neuroinflammation remain poorly understood. Here, we investigated the spatial and temporal expression of YAP\/TAZ in glial cells under lipopolysaccharide (LPS)\u2010induced neuroinflammation in mice. Immunofluorescence revealed selective upregulation and nuclear translocation of YAP\/TAZ in astrocytes within the spinal cord and specific brain regions following LPS injection, while microglial expression remained negligible. To further elucidate YAP\/TAZ\u2010related molecular responses, we performed RNA\u2010sequencing of spinal cord tissue on Day 3 post\u2010LPS injection. Transcriptomic analysis revealed significant upregulation of glial activation markers (\n                    <jats:italic>Aif1<\/jats:italic>\n                    ,\n                    <jats:italic>Tmem119<\/jats:italic>\n                    ,\n                    <jats:italic>Vim<\/jats:italic>\n                    ) and YAP\/TAZ\u2010associated genes involved in mechanosensation (\n                    <jats:italic>Piezo1<\/jats:italic>\n                    ), inflammasome signaling (\n                    <jats:italic>Nlrp3<\/jats:italic>\n                    ), and immune cell adhesion (\n                    <jats:italic>Icam1<\/jats:italic>\n                    ,\n                    <jats:italic>Vcam1<\/jats:italic>\n                    ). These results suggest that YAP\/TAZ may integrate mechanical and immune\u2010inflammatory cues in astrocytes and contribute to glial activation and neurovascular modulation under inflammatory conditions. Our study highlights the context\u2010dependent role of YAP\/TAZ in central nervous system inflammation and underscores their potential as therapeutic targets in neuroinflammatory diseases.\n                  <\/jats:p>","DOI":"10.1002\/glia.70129","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T07:01:49Z","timestamp":1766732509000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Regional and Cell\u2010Type\u2010Specific Activation of\n                    <scp>YAP<\/scp>\n                    \/\n                    <scp>TAZ<\/scp>\n                    Underlies Glial Responses in\n                    <scp>LPS<\/scp>\n                    \u2010Induced Neuroinflammation"],"prefix":"10.1002","volume":"74","author":[{"given":"Tae Woo","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Convergence Medical Science, College of Korean Medicine Kyung Hee University  Seoul Republic of Korea"},{"name":"Department of Science in Korean Medicine, Graduate School Kyung Hee University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujeong","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Convergence Medical Science, College of Korean Medicine Kyung Hee University  Seoul Republic of Korea"},{"name":"Department of Science in Korean Medicine, Graduate School Kyung Hee University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo\u2010Sung","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Convergence Medical Science, College of Korean Medicine Kyung Hee University  Seoul Republic of Korea"},{"name":"Department of Science in Korean Medicine, Graduate School Kyung Hee University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1036-0494","authenticated-orcid":false,"given":"Ik\u2010Hyun","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Convergence Medical Science, College of Korean Medicine Kyung Hee University  Seoul Republic of Korea"},{"name":"Department of Science in Korean Medicine, Graduate School Kyung Hee University  Seoul Republic of Korea"},{"name":"KHU\u2010KIST Department of Converging Science and Technology, Kyung Hee University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,25]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201046531\u20101"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201014198\u20108"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201034432\u20100"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018\u2010020\u201000150\u2010z"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty560"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113428"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.12.004"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201007022\u20102"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.695670"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010023\u201000644\u20105"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010022\u201001191\u20109"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.741060"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001588\u20100"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2018.08.003"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.777680"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24467"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.938416"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113431"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035\u2010020\u201000221\u20102"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.09.021"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adi7828"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264\u2010024\u201001308\u2010w"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1279591"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.adc9656"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.87"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4197"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00005.2014"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010023\u201000809\u2010y"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2019.5308"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201014353\u20106"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.504"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010018\u20100142\u2010z"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201022987\u20103"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.340"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.60031"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.2229\u201019.2020"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.0800\u201016.2016"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13465"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423\u2010023\u201001054\u20105"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13577\u2010021\u201000600\u20105"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010021\u201004203\u20108"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001486\u20105"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.03.028"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107507"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.70129","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/glia.70129","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.70129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}]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