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The field of spinal cord injury (SCI) is one such area that has experienced an increased implementation of genomic technologies within recent years. Innovative genomic tools have proven to be particularly useful for delving into the progression of SCI pathology and plasticity that is highly dynamic, temporal, and involves the close coordination and signaling of many different central nervous system resident and non\u2010resident cells. Neuroglia, in particular, have been extensively profiled, resulting in a deeper understanding of how neuroglia phenotypes and molecular signaling interact and progress after a spinal cord injury. In this review, we summarize some of the major discoveries that have enlightened and\/or shifted our current understanding of the role of neuroglia in injury potentiation and repair. Additionally, through a meta\u2010analysis of five SCI single\u2010cell time course atlases, we uncover insights and cautions regarding how injury model, time course, sample preparation, cellular categorization, and analytical approach impact the interpretation of any new genomic research in this field.<\/jats:p>","DOI":"10.1002\/glia.70139","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T06:09:35Z","timestamp":1775282975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Glia Are Bussin\u2019: How Single\u2010Cell and Spatial Transcriptomics Enlighten the Role of Neuroglia in Spinal Cord Injury and Regeneration"],"prefix":"10.1002","volume":"74","author":[{"given":"Julio","family":"Mejia","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Center for Neuroregeneration, Houston Methodist Research Institute  Houston Texas USA"},{"name":"Physiology, Biophysics 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