{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:21:43Z","timestamp":1790914903921,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["24wm0425005h0004"],"award-info":[{"award-number":["24wm0425005h0004"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["24ek0109764h0001"],"award-info":[{"award-number":["24ek0109764h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020237","name":"Japan Health Research Promotion Bureau","doi-asserted-by":"publisher","award":["2020\u2010B\u201007"],"award-info":[{"award-number":["2020\u2010B\u201007"]}],"id":[{"id":"10.13039\/100020237","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020237","name":"Japan Health Research Promotion Bureau","doi-asserted-by":"publisher","award":["2024\u2010D\u201001"],"award-info":[{"award-number":["2024\u2010D\u201001"]}],"id":[{"id":"10.13039\/100020237","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","award":["2024049458"],"award-info":[{"award-number":["2024049458"]}],"id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In the mammalian cerebellum, three types of astroglial cells\u2014Bergmann glial cells (BGs), inner granule cell layer (IGL) astrocytes, and white matter (WM) astrocytes\u2014arise in postnatal timing from two types of progenitors: Bergmann glia\u2010like progenitors (BGLPs) and astrocyte\u2010like progenitors (AsLPs). In contrast to AsLPs, which are commonly observed in other brain regions, BGLPs have not been well studied. Here, we investigate differentiation abilities, gene expression profiles and differentiation control mechanisms of BGLPs at postnatal stages. BGLPs and AsLPs decrease in number as development progresses from postnatal day 0 (P0), and are almost absent by P10. By utilizing an electroporation\u2010based method to BGLPs, we found that P6 BGLPs differentiate into BGs and IGL astrocytes, but not into WM astrocytes, consistent with a previous report. However, P0 BGLPs were observed to differentiate into not only BGs and IGL astrocytes, but also WM astrocytes and a small number of molecular layer inhibitory neurons. By conducting spatial transcriptomic analysis with over 5000 probes (Xenium), we successfully identified distinct clusters corresponding to BGLPs at P0 and P6, respectively, and genes preferentially expressed in P0 and P6 BGLPs. In addition, upstream regulatory analysis using Enrichr identified\n                    <jats:italic>Foxm1<\/jats:italic>\n                    and\n                    <jats:italic>Nfia<\/jats:italic>\n                    as candidate regulators that affect stage\u2010specific properties of BGLPs. in\u00a0vivo knockdown and overexpression experiments further demonstrated that precise regulation of\n                    <jats:italic>Foxm1<\/jats:italic>\n                    and\n                    <jats:italic>Nfia<\/jats:italic>\n                    expression is important for proper progeny production from postnatal BGLPs. This study gives insights into understanding molecular nature and differentiation ability control of BGLPs during postnatal cerebellar development.\n                  <\/jats:p>","DOI":"10.1002\/glia.70160","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:55:24Z","timestamp":1782460524000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Molecular Characteristics and Differentiation Control Mechanisms of Bergmann Glia\u2010Like Progenitors in the Postnatal Mouse Cerebellum"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2957-6044","authenticated-orcid":false,"given":"Kyoka","family":"Suyama","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Cellular Biology National Center of Neurology and Psychiatry (NCNP)  Tokyo Japan"},{"name":"Graduate School of Medical and Dental Sciences, Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1519-9310","authenticated-orcid":false,"given":"Toma","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Cellular Biology National Center of Neurology and Psychiatry (NCNP)  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minami","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Cellular Biology National Center of Neurology and Psychiatry (NCNP)  Tokyo Japan"},{"name":"Department of Biomolecular Science, Faculty of Science Toho University  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6817-6032","authenticated-orcid":false,"given":"Kaiyuan","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Cellular Biology National Center of Neurology and Psychiatry (NCNP)  Tokyo 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