{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:41:00Z","timestamp":1788446460381,"version":"build-2803163510"},"reference-count":88,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202307650016"],"award-info":[{"award-number":["202307650016"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202207650034"],"award-info":[{"award-number":["202207650034"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021790","name":"Fondation pour la Recherche sur Alzheimer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G057623N"],"award-info":[{"award-number":["G057623N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G005224N"],"award-info":[{"award-number":["G005224N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004681","name":"Higher Education Commission, Pakistan","doi-asserted-by":"publisher","award":["1(2)\/HRD\/OSS\u2010III\/2022\/HEC\/439"],"award-info":[{"award-number":["1(2)\/HRD\/OSS\u2010III\/2022\/HEC\/439"]}],"id":[{"id":"10.13039\/501100004681","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004681","name":"Higher Education Commission, Pakistan","doi-asserted-by":"publisher","award":["1(2)\/HRD\/OSS\/III\/2020\/HEC\/1"],"award-info":[{"award-number":["1(2)\/HRD\/OSS\/III\/2020\/HEC\/1"]}],"id":[{"id":"10.13039\/501100004681","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007229","name":"Bijzonder Onderzoeksfonds UGent","doi-asserted-by":"publisher","award":["BOF23\/GOA\/015"],"award-info":[{"award-number":["BOF23\/GOA\/015"]}],"id":[{"id":"10.13039\/501100007229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007229","name":"Bijzonder Onderzoeksfonds UGent","doi-asserted-by":"publisher","award":["BOF\/STA\/202109\/012"],"award-info":[{"award-number":["BOF\/STA\/202109\/012"]}],"id":[{"id":"10.13039\/501100007229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Herpes simplex virus type 1 (HSV1) is a highly prevalent neurotropic pathogen that causes a wide range of diseases, including cold sores, blinding keratitis, and life\u2010threatening encephalitis. HSV1 first replicates in the epithelial cells of the oronasal\u00a0mucosa and enters the peripheral nervous system (PNS) to establish latency in sensory neurons. HSV1 persistence in the\u00a0host has been associated with neurological diseases, including multiple sclerosis. Several in\u00a0vivo studies reported that HSV1 infection can cause PNS and CNS demyelination; however, the viral pathogenesis remains unclear. Schwann cells (SCs) are the main myelinating cells of the PNS, but it is unknown whether they can be infected by HSV1. Here, we demonstrated that HSV1 productively infects SCs, but the infection efficiency is viral strain\u2010dependent. We showed that HSV1 downregulates the expression of the myelin\u2010related PMP22 gene at late stages of infection. In\u00a0vivo studies confirmed that HSV1 infection induces PNS demyelination with a clear loss of myelin basic protein (MBP) expression observed in infected\u00a0tissues\u00a0together with the presence of demyelinating lesions. Besides, we demonstrated that HSV1 hijacks the multivesicular bodies (MVB)\u2010exosomal pathway in SCs in\u00a0vitro for efficient infection and spread. TEM confirmed the presence of MVB containing virions and the release of extracellular vesicles with virions near the plasma membrane. By function\u2010blocking antibody and siRNA treatments, we demonstrated that HSV1 uses tetraspanin CD81 as the main entry receptor in SCs. Overall, this study provides new insights into the role of SCs in the pathogenesis of herpesviruses and viral\u2010induced demyelination processes.<\/jats:p>","DOI":"10.1002\/glia.70178","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:35:37Z","timestamp":1781588137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Herpes Simplex Virus Type 1 Infects Schwann Cells via Exosomal\n                    <scp>CD81<\/scp>\n                    , Exploits the\n                    <scp>MVB<\/scp>\n                    \u2013Exosomal Pathway, and Induces Demyelination"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5332-2556","authenticated-orcid":false,"given":"Xixi","family":"Kang","sequence":"first","affiliation":[{"name":"Laboratory of Virology, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine Ghent University  Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7853-9036","authenticated-orcid":false,"given":"Freyja","family":"Vanden Broucke","sequence":"additional","affiliation":[{"name":"UGent TEM Core Facility, Department of Morphology, Imaging, Orthopedics, Rehabilitation and Nutrition, Faculty of Veterinary Medicine Ghent University  Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6566-2534","authenticated-orcid":false,"given":"Anita","family":"Yousefi","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine Ghent University  Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0440-0840","authenticated-orcid":false,"given":"Ya","family":"Gao","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine Ghent University  Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1986-379X","authenticated-orcid":false,"given":"Waqar","family":"Zaib","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine Ghent University  Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6683-5658","authenticated-orcid":false,"given":"Wim","family":"Van Den Broeck","sequence":"additional","affiliation":[{"name":"UGent TEM Core Facility, Department of Morphology, Imaging, Orthopedics, Rehabilitation and Nutrition, Faculty of Veterinary Medicine Ghent University  Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6540-7114","authenticated-orcid":false,"given":"Waqar","family":"Saleem","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine Ghent University  Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2539-8209","authenticated-orcid":false,"given":"Olivier","family":"Schollaert","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine Ghent University  Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1920-8456","authenticated-orcid":false,"given":"Moloud","family":"Jalilishahmansouri","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine Ghent University  Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0979-2827","authenticated-orcid":false,"given":"Tommy","family":"Teirlynck","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine Ghent University  Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2861-9904","authenticated-orcid":false,"given":"Sof\u00eda Gonz\u00e1lez","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine Ghent University  Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2729-3312","authenticated-orcid":false,"given":"Febe","family":"Lippens","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine Ghent University  Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8289-9411","authenticated-orcid":false,"given":"Camille","family":"Kaviani","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine Ghent University  Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4073-016X","authenticated-orcid":false,"given":"Joren","family":"Portaels","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine Ghent University  Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6873-4110","authenticated-orcid":false,"given":"Kathlyn","family":"Laval","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine Ghent University  Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.73.1.377\u2010387.1999"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00442"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.58.1.31"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21145026"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02572"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104939\u20109814\u20102_17"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00088\u201018"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12060623"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410260218"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70353"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01161\u201019"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/00368504241312073"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23272"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007754"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201001004\u2010y"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201046389\u20100"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02411"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.68.2.834\u2010845.1994"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010023\u201000709\u20106"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.40.1.103\u2010112.1983"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2022.105084"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022\u20101317\u20102\u20103\u2010357"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0065\u20103527(08)60787\u20103"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13122364"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/v6020535"},{"key":"e_1_2_12_27_1","unstructured":"Ga Y. I.Langenhove J.Moloud et\u00a0al. Unpublished data2026."},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/neuroglia5010001"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.346478"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014\u20104886(64)90008\u20101"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23848"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20184"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.73.10.8503\u20108511.1999"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.76.1.1\u20108.2002"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985\u2010016\u20100518\u20102"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410220113"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072\u2010199207000\u201000005"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S500159"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.12.007"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2022.1041961"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.03.010"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00276\u201015"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/v5020678"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u2010510x(79)90119\u20109"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u2010510x(82)90006\u20105"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.7860\/jcdr\/2016\/17949.8022"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750\u20103639.2007.00064.x"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.658695"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000375"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1086\/651430"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010012\u20108370\u2010x"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2019.4218"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140765"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01739\u201019"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1205906"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00623\u201025"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009441"},{"key":"e_1_2_12_58_1","first-page":"493","article-title":"A Simple Method of Estimating Fifty Per Cent Endpoints","volume":"27","author":"Muench L. J.","year":"1938","journal-title":"American Journal of Hygiene"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000001370"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574\u20106976.2011.00320.x"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2023.1248922"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1042\/NS20170166"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.445304"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5390.938"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010020\u201001074\u20106"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2232366100"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102567.2002.01421.x"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.531"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13275"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.3109\/13550289609146888"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1996.00550020029012"},{"issue":"3","key":"e_1_2_12_72_1","first-page":"483","article-title":"Molecular Anatomy and Genetics of Myelin Proteins in the Peripheral Nervous System","volume":"186","author":"Snipes G. J.","year":"1995","journal-title":"Journal of Anatomy"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01241\u201008"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20231359"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00609\u201020"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.75.21.10401\u201010408.2001"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010neuro\u2010110920\u2010030610"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902192"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072\u2010198107000\u201000002"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072\u2010198309000\u201000005"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072\u2010198607000\u201000004"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12112"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750\u20101172\u20109\u201038"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1965.00970030114023"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v4.27066"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110026"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.78.3.1448\u20101455.2004"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1571"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361\u20109230(95)00040\u20102"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.70178","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/glia.70178","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.70178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:35:41Z","timestamp":1781588141000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.70178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,15]]},"references-count":88,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/glia.70178"],"URL":"https:\/\/doi.org\/10.1002\/glia.70178","archive":["Portico"],"relation":{},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,15]]},"assertion":[{"value":"2025-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70178"}}