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Ongoing nociceptive inputs from peripheral injuries lead to maladaptive alterations in the central nervous system during the transition from acute to chronic pain, which in turn contribute to the maintenance of chronic pain and reduce the effectiveness of peripheral analgesics. Reactive astrocytes are known to contribute to chronic neuropathic pain in the spinal cord, while how astrocytes contribute to chronic pain in supraspinal nuclei remains unclear. This study reveals that continuous painful stimulation from peripheral injury induces astrocyte reactivity and downregulation of astrocytic Kir4.1 (inward rectifying potassium channel protein 4.1) in the paraventricular thalamus (PVT). In turn, these reactive astrocytes help to maintain neuronal hyperactivity in the PVT and enhance neural projections from PVT to the medial prefrontal cortex (mPFC), which contribute to hyperalgesia in chronic neuropathic pain. Therefore, this study identifies a neuro\u2010glial interaction that mediates chronic pain in supraspinal brain.<\/jats:p>","DOI":"10.1002\/glia.70183","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:55:26Z","timestamp":1780466126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sustained Neuronal Stimulation Activates Paraventricular Thalamus Astrocytes for Chronicity of Neuropathic Pain in Mice"],"prefix":"10.1002","volume":"74","author":[{"given":"Yi","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Anesthesiology West China Hospital of Sichuan University  Chengdu China"},{"name":"Research Institution of Anesthesiology, National\u2010Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University  Chengdu 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