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While oxygen availability controls oligodendrocyte (OL) differentiation, prolonged hypoxia leads to OL death and impairs subsequent myelination even after returning to normoxic conditions. In this study, we uncovered the detrimental roles of the serine\/threonine kinase CK2\u03b1 and the transcriptional factor Bclaf1 in OL survival under hypoxic conditions. Phosphorylated Bclaf1 by CK2\u03b1 drives hypoxia\u2010mediated OL apoptosis, which can be reversed by introducing the hypoxia\u2010inducible E3 ligase Vhl. Additionally, acute treatment with the clinically approved CK2 inhibitor silmitasertib and the herbal supplement curcumin not only reduces CK2\u03b1\u2010Bclaf1 activity but also protects OLs and restores pre\u2010myelinating ability in newborns following hypoxic injury. This approach unveils a key molecular regulation in hypoxia\u2010related OL pathology and highlights a potential therapeutic strategy to mitigate neonatal hypoxic injury and prevent mental health complications.<\/jats:p>","DOI":"10.1002\/glia.70187","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:03:25Z","timestamp":1782975805000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Blocking\n                    <scp>CK2\u03b1<\/scp>\n                    \u2010Bclaf1 Preserves Oligodendrocytes After Neonatal Hypoxic Injury"],"prefix":"10.1002","volume":"74","author":[{"given":"Chien\u2010Fang","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Biotechnology and Bioindustry Sciences National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ti\u2010Jie","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioindustry Sciences National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioindustry Sciences National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Ting","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8270-6491","authenticated-orcid":false,"given":"Chih\u2010Yen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioindustry Sciences National Cheng Kung University  Tainan Taiwan"},{"name":"University Center for Bioscience and Biotechnology National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advenzreg.2008.04.002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.09.019"},{"issue":"6","key":"e_1_2_10_4_1","first-page":"1557","article-title":"Curcumin Inhibits Hypoxia\u2010Induced Angiogenesis via Down\u2010Regulation of HIF\u20101","volume":"15","author":"Bae M. 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