{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:29:58Z","timestamp":1787758198498,"version":"build-2784847793"},"reference-count":70,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Myelinogenesis is insufficient in numerous myelin\u2010related diseases in the CNS, leading to functional impairments. Myelinogenesis couples with angiogenesis to ensure adequate need of oxygen and nutrients for oligodendrocyte (OL) differentiation. However, approaches to synchronize myelino\u2010vascular coupling remain unavailable. We hypothesize the identification of shared signaling pathways in vascular cells and oligodendroglia may yield novel strategies to promote myelin repair through strengthening the blood vessel\u2010myelination coupling. Here, single\u2010cell sequencing and in\u00a0situ hybridization revealed high expression of G\u2010protein\u2010coupled receptor 30 (\n                    <jats:italic>Gpr30<\/jats:italic>\n                    ) in both vascular cells and oligodendroglia, with selective enrichment in pericytes and oligodendrocyte precursor cells (OPCs). Cell\u2010specific deletion of GPR30 in pericytes driven by PDGFR\u03b2\n                    <jats:sup>CreERT2<\/jats:sup>\n                    resulted in enhanced angiogenesis and myelination in developing brains. GPR30 deletion in OPCs or antagonizing GPR30 by G15 resulted in increased MBP\u2010positive cell density and enhanced nanofiber wrapping capacity in\u00a0vitro, thereby demonstrating an inhibiting role of GPR30 on OPC differentiation. To elucidate the coordinative role of GPR30 in both cell types, we employed NG2\n                    <jats:sup>CreERT<\/jats:sup>\n                    to induce a conditional knockout of GPR30 in both NG2\u2010positive pericytes and OPCs. The conditional deletion of GPR30 enhanced myelination and increased vascular density in developing brains. Further, GPR30 cKO or G15 treatment enhanced myelin repair and functional recovery in the chronic neonatal hypoxia and lysolecithin\u2010induced demyelination model, suggesting that antagonizing GPR30 is a promising strategy to synchronize angiogenesis with myelination to promote myelinogenesis. These findings establish GPR30 antagonism as a promising approach to enhance myelin repair through synchronizing pericyte\u2010mediated angiogenesis and OPC differentiation.\n                  <\/jats:p>","DOI":"10.1002\/glia.70206","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:39:32Z","timestamp":1786541972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>GPR30<\/scp>\n                    Functions as a Shared Inhibitory Signal for Both Pericyte\u2010Mediated Angiogenesis and Oligodendrocyte Myelination"],"prefix":"10.1002","volume":"74","author":[{"given":"Si\u2010Wen","family":"Hui","sequence":"first","affiliation":[{"name":"Brain and Intelligence Research Key Laboratory of Chongqing Education Commission, Department of Histology and Embryology Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Gao","sequence":"additional","affiliation":[{"name":"Brain and Intelligence Research Key Laboratory of Chongqing Education Commission, Department of Histology and Embryology Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery of Xinqiao Hospital Third Military Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4959-1345","authenticated-orcid":false,"given":"Qi\u2010Jing","family":"Lei","sequence":"additional","affiliation":[{"name":"Center for Medical Epigenetics, Department of Physiology School of Basic Medical Sciences, Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Brain and Intelligence Research Key Laboratory of Chongqing Education Commission, Department of Histology and Embryology Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang\u2010Ling","family":"Wu","sequence":"additional","affiliation":[{"name":"Brain and Intelligence Research Key Laboratory of Chongqing Education Commission, Department of Histology and Embryology Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Jie","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xiamen University Affiliated Chenggong Hospital  Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Histology and Embryology and K.K. Leung Brain Research Centre The Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Brain and Intelligence Research Key Laboratory of Chongqing Education Commission, Department of Histology and Embryology Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5675-6731","authenticated-orcid":false,"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Brain and Intelligence Research Key Laboratory of Chongqing Education Commission, Department of Histology and Embryology Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Mei","sequence":"additional","affiliation":[{"name":"Brain and Intelligence Research Key Laboratory of Chongqing Education Commission, Department of Histology and Embryology Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Emergence 5th People's Hospital of Chongqing  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Brain and Intelligence Research Key Laboratory of Chongqing Education Commission, Department of Histology and Embryology Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.03.045"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.07.003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010017\u20101718\u20106"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.10.085"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.871"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio775"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2025795118"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2652"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","unstructured":"Call C. 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