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They extend their processes and migrate toward injuries in\u00a0vivo. However, how the fractalkine receptor (CX3CR1) influences microglial migration remains unknown. Label\u2010free proteomic profiling predicted changes in Ras homology family (RHO)\u2010signaling activity that hint at dysregulated cytoskeleton signaling in\n                    <jats:italic>Cx3cr1\u2010<\/jats:italic>\n                    deficient murine cortex tissue. To further investigate microglial migration, we carried out two\u2010photon in\u00a0vivo imaging at 4\u2010h intervals for 72\u2009h after a laser lesion in the cortex.\n                    <jats:italic>Cx3cr1<\/jats:italic>\n                    \u2010deficient microglia showed enhanced migration toward the lesion. Additionally, the length and velocity of microglial fine processes extending toward the lesion were increased in\n                    <jats:italic>Cx3cr1\u2010<\/jats:italic>\n                    deficient microglia. Migration remained unchanged in\n                    <jats:italic>Ccr2<\/jats:italic>\n                    \u2010deficient mice, indicating that monocyte\u2010derived macrophages\/microglia did not contribute to microglia accumulation around the lesion. These results demonstrate that CX3CR1 modulates microglia migration toward laser\u2010induced CNS injury. Manipulating microglia migration via the CX3CR1 signaling axis is therefore a potential target for the treatment of CNS injury.\n                  <\/jats:p>","DOI":"10.1002\/glia.70207","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T07:40:52Z","timestamp":1786779652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CX3CR1<\/scp>\n                    Modulates Migration of Resident Microglia Towards Cortical Laser\u2010Induced Lesions"],"prefix":"10.1002","volume":"74","author":[{"given":"Jens","family":"Wagner","sequence":"first","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2955-7368","authenticated-orcid":false,"given":"Henrike","family":"Antony","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative 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