{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:58:48Z","timestamp":1790395128225,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01EY026147"],"award-info":[{"award-number":["R01EY026147"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R01EY035702"],"award-info":[{"award-number":["R01EY035702"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007745","name":"Massachusetts Lions Eye Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007745","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The cornea depends on trigeminal sensory innervation for sensation and epithelial homeostasis, yet cell type\u2013specific transcriptional responses in the trigeminal ganglion following corneal injury remain incompletely defined. To address this gap, we combined bulk and single\u2010cell RNA sequencing to profile the mouse trigeminal ganglion after a moderate corneal alkali injury associated with transient denervation and an early phase of nerve regeneration. Corneal injury elicited a robust early transcriptional response dominated by glial populations. In myelinating Schwann cells, injury responses were characterized by transcriptional programs supporting neuronal communication and remodeling of inflammatory signaling, while nonmyelinating Schwann cells and satellite glia showed strong enrichment of proteostasis\u2010related pathways. Single\u2010cell analysis further revealed that neurons responded to injury by downregulating protein translation and mitochondrial activity. In parallel, inference of ligand\u2013receptor interactions indicated that early injury responses involved extensive neuron\u2013glia communication, whereas later responses became more neuron\u2010centered, reflecting a shift toward neuron\u2010derived ligand signaling. Together, these data define a corneal injury\u2013associated transcriptional landscape of the trigeminal ganglion characterized by prominent glial proteostasis responses and a time\u2010dependent reorganization of neuron\u2013glia communication.<\/jats:p>","DOI":"10.1002\/glia.70226","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:00:12Z","timestamp":1789012812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single\u2010Cell Profiling Identifies Glial Transcriptional Remodeling in the Trigeminal Ganglion After Corneal Injury"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4045-8123","authenticated-orcid":false,"given":"Ashley M.","family":"Woodward","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Tufts Medical Center, Tufts University School of Medicine  Boston Massachusetts 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