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Despite advances in elucidating its genetic basis, effective therapeutic strategies remain limited. Recent studies indicate that astrocytes in AxD exhibit excessive mitochondrial fragmentation, which may cause mitochondrial dysfunction and inflammatory response. Photobiomodulation (PBM) has been shown to improve mitochondrial function and exert anti\u2010inflammatory effects, suggesting it may be a promising candidate for the treatment of AxD. Here, we report that exposure to 1070\u2010nm infrared light exerts therapeutic efficacy in AxD. Specifically, using the astrocytes derived from AxD patients and a mouse model of AxD, we demonstrate that PBM regulates AMPK\/mTOR signaling and promotes mitophagy, thereby attenuating reactive oxygen species production from fragmented mitochondria and subsequent inflammatory status. This study suggests PBM may serve as a novel, non\u2010invasive therapeutic approach for the treatment of AxD.<\/jats:p>","DOI":"10.1002\/glia.70229","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:13:12Z","timestamp":1791263592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photobiomodulation Ameliorates Alexander Disease Through\n                    <scp>AMPK<\/scp>\n                    \/\n                    <scp>mTOR<\/scp>\n                    \u2010Mediated Mitophagy"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6786-1269","authenticated-orcid":false,"given":"Nianzhuang","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Neurobiology School of Basic Medical Sciences, National Institute on Drug Dependence, Peking University  Beijing China"},{"name":"Beijing Key Laboratory of Innovative Intervention 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