{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:58:39Z","timestamp":1790395119362,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["25POST1363224"],"award-info":[{"award-number":["25POST1363224"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pediatric obstructive sleep apnea (POSA) is a common childhood disease that often causes aberrant brain development and cognitive deficits. The pathophysiological underpinnings of cognitive impairments in POSA remain unclear. Here, we examined cellular and molecular aspects of pathology in a mouse model of POSA that features learning and memory deficits. We performed single\u2010nucleus RNA\u2010sequencing (snRNA\u2010seq) of the hippocampus to examine gene expression changes in an unbiased and cell type\u2010specific manner. This dataset revealed a striking perturbation of transcriptomes across all brain cell types, particularly within glia and neural stem cells. We validated reduced expression of several differentially expressed genes at protein level: QDPR and SOX8 in oligodendrocytes, LRRK2 and NDUFS4 in neural stem cells, TFE3 in microglia, and GLUT1 in astrocytes. Comparison of oligodendrocyte gene expression changes with proteomic datasets suggested impairments in myelination, which we confirmed in\u00a0vivo. Furthermore, cellular level analyses demonstrated aberrant morphology of oligodendrocytes, astrocytes, and microglia in the hippocampus, and diminished numbers of neural stem cells in the subgranular zone. Our study identifies cellular and molecular glial cell dysfunction in POSA, validates gene targets for further study, and provides an snRNA\u2010seq dataset to facilitate further data\u2010driven hypothesis generation.<\/jats:p>","DOI":"10.1002\/glia.70230","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:52:20Z","timestamp":1789789940000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glial Dysfunction and Memory Impairments in a Model of\u00a0Pediatric Obstructive Sleep Apnea"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8049-4463","authenticated-orcid":false,"given":"Michael R.","family":"Williamson","sequence":"first","affiliation":[{"name":"Program in Neurosciences and Mental Health The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Department of Physiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7292-8981","authenticated-orcid":false,"given":"Jorge","family":"Botas","sequence":"additional","affiliation":[{"name":"Data Science Center Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital  Houston Texas USA"},{"name":"Department of Pediatrics Baylor College of Medicine  Houston Texas USA"},{"name":"Jan and Dan Duncan Neurological Research Institute Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3096-0606","authenticated-orcid":false,"given":"Mahyar J.","family":"Hedayatpour","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Perioperative and Pain Medicine, Texas Children's Hospital  Houston Texas USA"},{"name":"Department of Anesthesiology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6922-6407","authenticated-orcid":false,"given":"Thea","family":"Zlatkov","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Baylor College of Medicine  Houston Texas USA"},{"name":"Center for Cell and Gene Therapy Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6374-9041","authenticated-orcid":false,"given":"Akdes Serin","family":"Harmanci","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0884-1122","authenticated-orcid":false,"given":"Christopher J.","family":"Yates","sequence":"additional","affiliation":[{"name":"Data Science Center Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital  Houston Texas USA"},{"name":"Department of Pediatrics Baylor College of Medicine  Houston Texas USA"},{"name":"Jan and Dan Duncan Neurological Research Institute Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0708-7245","authenticated-orcid":false,"given":"Kenneth","family":"Nobleza","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshan","family":"Ailani","sequence":"additional","affiliation":[{"name":"Jan and Dan Duncan Neurological Research Institute Texas Children's Hospital  Houston Texas USA"},{"name":"Department of Neuroscience Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6518-1549","authenticated-orcid":false,"given":"Adam C.","family":"Adler","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Perioperative and Pain Medicine, Texas Children's Hospital  Houston Texas USA"},{"name":"Department of Anesthesiology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farrah","family":"Kheradmand","sequence":"additional","affiliation":[{"name":"Translational Biology and Molecular Medicine Program Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Medicine Baylor College of Medicine  Houston Texas USA"},{"name":"Dan L. Duncan Comprehensive Cancer Center Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Pathology and Immunology Baylor College of Medicine  Houston Texas USA"},{"name":"Center for Translational Research in Inflammatory Diseases Michael E. DeBakey VA  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5793-4398","authenticated-orcid":false,"given":"Hyun Kyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Jan and Dan Duncan Neurological Research Institute Texas Children's Hospital  Houston Texas USA"},{"name":"Department of Neuroscience Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Pediatrics Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6335-1081","authenticated-orcid":false,"given":"Benjamin","family":"Deneen","sequence":"additional","affiliation":[{"name":"Center for Cell and Gene Therapy Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Neurosurgery Baylor College of Medicine  Houston Texas USA"},{"name":"Center for Cancer Neuroscience Baylor College of Medicine  Houston Texas 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