{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:55:42Z","timestamp":1790769342410,"version":"4.1.0"},"reference-count":99,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102026\u201004461"],"award-info":[{"award-number":["RGPIN\u20102026\u201004461"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT\u2010156164"],"award-info":[{"award-number":["PJT\u2010156164"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Myelin regulates neural signaling not only by enabling fast conduction but also by dynamically tuning axonal conduction velocity (CV) and thereby shaping spike timing. While activity\u2010dependent myelination is thought to optimize neural communication, how changes in myelin translate into altered single\u2010cell dynamics and plasticity remains unclear. Using a computational modeling approach, we show that disruptions of axonal CV reorganize presynaptic input correlations, leading to systematic changes in postsynaptic excitability, excitation\u2013inhibition balance, and spike\u2010timing\u2010dependent plasticity. By spanning CV regimes associated with healthy myelination, demyelination, and excessive myelination, our simulations illustrate how both deficient and excessive CV could induce maladaptive neuronal dynamics. The incorporation of firing\u2010rate homeostasis into our models further suggests distinct neuronal dynamic consequences for acute versus chronic myelin disruption. Ultimately, these results suggest that axonal CV may serve as a key mechanistic link between myelin plasticity and neural computation, offering a principled framework to interpret the functional consequences of myelin dysregulation in health and disease.<\/jats:p>","DOI":"10.1002\/glia.70231","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:02:54Z","timestamp":1790766174000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Computational Framework for Myelin as a Regulator of Temporal Integration, Neuronal Excitability, and Synaptic Plasticity"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1403-6491","authenticated-orcid":false,"given":"Daniel","family":"O'Sullivan","sequence":"first","affiliation":[{"name":"Department of Biology University of Ottawa  Ottawa Ontario Canada"},{"name":"Department of Cellular and Molecular Medicine University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1601-2826","authenticated-orcid":false,"given":"Aref","family":"Pariz","sequence":"additional","affiliation":[{"name":"Department of Biology University of Ottawa  Ottawa Ontario Canada"},{"name":"Krembil Brain Institute, University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8401-2320","authenticated-orcid":false,"given":"Daniel","family":"Trotter","sequence":"additional","affiliation":[{"name":"Department of Physics University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3483-4551","authenticated-orcid":false,"given":"Noor Z.","family":"Al Dahhan","sequence":"additional","affiliation":[{"name":"Neuroscience and Mental Health The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9214-2991","authenticated-orcid":false,"given":"Juliet K.","family":"Knowles","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Sciences Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1395-3586","authenticated-orcid":false,"given":"Paul W.","family":"Frankland","sequence":"additional","affiliation":[{"name":"Neuroscience and Mental Health The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Department of Physiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6161-5066","authenticated-orcid":false,"given":"Donald","family":"Mabbott","sequence":"additional","affiliation":[{"name":"Neuroscience and Mental Health The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Department of Psychology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0369-4565","authenticated-orcid":false,"given":"J\u00e9r\u00e9mie","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"Department of Biology University of Ottawa  Ottawa Ontario Canada"},{"name":"Krembil Brain Institute, University Health Network  Toronto Ontario Canada"},{"name":"Department of Physics University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.1016\/j.neuron.2021.07.031","article-title":"What Is the Dynamical Regime of Cerebral Cortex?","volume":"109","author":"Ahmadian Y.","year":"2021","journal-title":"Neuron"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"10023","DOI":"10.1523\/JNEUROSCI.3185-16.2017","article-title":"On Myelinated Axon Plasticity and Neuronal Circuit Formation and Function","volume":"37","author":"Almeida R. G.","year":"2017","journal-title":"Journal of Neuroscience"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2222016120","article-title":"Gating of Homeostatic Regulation of Intrinsic Excitability Produces Cryptic Long\u2010Term Storage of Prior Perturbations","volume":"120","author":"Alonso L. M.","year":"2023","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1088\/0954-898X_8_4_003","article-title":"Dynamics of a Recurrent Network of Spiking Neurons Before and Following Learning","volume":"8","author":"Amit D. J.","year":"1997","journal-title":"Network: Computation in Neural Systems"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.23329","article-title":"Node of Ranvier Length as a Potential Regulator of Myelinated Axon Conduction Speed","volume":"6","author":"Arancibia\u2010C\u00e1rcamo I. L.","year":"2017","journal-title":"eLife"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.cub.2018.01.017","article-title":"Evidence for Myelin Sheath Remodeling in the CNS Revealed by in Vivo Imaging","volume":"28","author":"Auer F.","year":"2018","journal-title":"Current Biology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/s41593-020-0637-3","article-title":"Motor Learning Promotes Remyelination via New and Surviving Oligodendrocytes","volume":"23","author":"Bacmeister C. M.","year":"2020","journal-title":"Nature Neuroscience"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/s41593-022-01169-4","article-title":"Motor Learning Drives Dynamic Patterns of Intermittent Myelination on Learning\u2010Activated Axons","volume":"25","author":"Bacmeister C. M.","year":"2022","journal-title":"Nature Neuroscience"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevE.99.052414","article-title":"Correlated States in Balanced Neuronal Networks","volume":"99","author":"Baker C.","year":"2019","journal-title":"Physical Review E"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.1093\/cercor\/bhac329","article-title":"Difference in Axon Diameter and Myelin Thickness Between Excitatory and Inhibitory Callosally Projecting Axons in Mice","volume":"33","author":"Basu K.","year":"2023","journal-title":"Cerebral Cortex"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1016\/j.cub.2015.07.056","article-title":"CNS Myelin Sheath Lengths Are an Intrinsic Property of Oligodendrocytes","volume":"25","author":"Bechler M. E.","year":"2015","journal-title":"Current Biology"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1002\/glia.23661","article-title":"White Matter Plasticity and Maturation in Human Cognition","volume":"67","author":"Bells S.","year":"2019","journal-title":"Glia"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"8227","DOI":"10.1523\/JNEUROSCI.0560-17.2017","article-title":"Changes in White Matter Microstructure Impact Cognition by Disrupting the Ability of Neural Assemblies to Synchronize","volume":"37","author":"Bells S.","year":"2017","journal-title":"Journal of Neuroscience"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1038\/s41467-020-18984-7","article-title":"Myelination of Parvalbumin Interneurons Shapes the Function of Cortical Sensory Inhibitory Circuits","volume":"11","author":"Benamer N.","year":"2020","journal-title":"Nature Communications"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"R110","DOI":"10.1016\/j.cub.2020.11.054","article-title":"Neural Adaptation","volume":"31","author":"Benda J.","year":"2021","journal-title":"Current Biology"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1162\/089976603322385063","article-title":"A Universal Model for Spike\u2010Frequency Adaptation","volume":"15","author":"Benda J.","year":"2003","journal-title":"Neural Computation"},{"key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"10464","DOI":"10.1523\/JNEUROSCI.18-24-10464.1998","article-title":"Synaptic Modifications in Cultured Hippocampal Neurons: Dependence on Spike Timing, Synaptic Strength, and Postsynaptic Cell Type","volume":"18","author":"Bi G.","year":"1998","journal-title":"Journal of Neuroscience: The Official Journal of the Society for Neuroscience"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1113\/jphysiol.1978.sp012384","article-title":"The Internodal Axon Membrane: Electrical Excitability and Continuous Conduction in Segmental Demyelination","volume":"280","author":"Bostock H.","year":"1978","journal-title":"Journal of Physiology"},{"key":"e_1_2_10_20_1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1162\/neco.2009.12-07-657","article-title":"Generation of Correlated Spike Trains","volume":"21","author":"Brette R.","year":"2009","journal-title":"Neural Computation"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1038\/s41467-021-25035-2","article-title":"Cortical Neurons Exhibit Diverse\u00a0Myelination Patterns That Scale Between Mouse Brain Regions and Regenerate After Demyelination","volume":"12","author":"Call C. L.","year":"2021","journal-title":"Nature Communications"},{"key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.neuron.2012.12.020","article-title":"Enhanced Intrinsic Excitability in Basket Cells Maintains Excitatory\u2010Inhibitory Balance in Hippocampal Circuits","volume":"77","author":"Campanac E.","year":"2013","journal-title":"Neuron"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/BF00288750","article-title":"Diffusion Approximation and First Passage Time Problem for a Model Neuron","volume":"8","author":"Capocelli R.","year":"1971","journal-title":"Kybernetik"},{"key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev.neuro.31.060407.125639","article-title":"Spike Timing\u2013Dependent Plasticity: A Hebbian Learning Rule","volume":"31","author":"Caporale N.","year":"2008","journal-title":"Annual Review of Neuroscience"},{"key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/s43588-022-00320-2","article-title":"The Role of ADM in Brain Function","volume":"2","author":"Chacron M. J.","year":"2022","journal-title":"Nature Computational Science"},{"key":"e_1_2_10_26_1","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nature06028","article-title":"Correlation Between Neural Spike Trains Increases With Firing Rate","volume":"448","author":"De La Rocha J.","year":"2007","journal-title":"Nature"},{"key":"e_1_2_10_27_1","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1126\/science.275.5307.1805","article-title":"Reproducibility and Variability in Neural Spike Trains","volume":"275","author":"Steveninck R. R.","year":"1997","journal-title":"Science"},{"key":"e_1_2_10_28_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.conb.2018.09.001","article-title":"Plasticity of Intrinsic Neuronal Excitability","volume":"54","author":"Debanne D.","year":"2019","journal-title":"Current Opinion in Neurobiology"},{"key":"e_1_2_10_29_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1209\/0295-5075\/4\/2\/007","article-title":"An Exactly Solvable Asymmetric Neural Network Model","volume":"4","author":"Derrida B.","year":"1987","journal-title":"Europhysics Letters"},{"key":"e_1_2_10_30_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/ene.13819","article-title":"Multiple Sclerosis\u2014A Review","volume":"26","author":"Dobson R.","year":"2019","journal-title":"European Journal of Neurology"},{"key":"e_1_2_10_31_1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nn.4242","article-title":"The Mechanics of State\u2010Dependent Neural Correlations","volume":"19","author":"Doiron B.","year":"2016","journal-title":"Nature Neuroscience"},{"key":"e_1_2_10_32_1","first-page":"E5361","article-title":"Ion Channel Degeneracy Enables Robust and Tunable Neuronal Firing Rates","volume":"112","author":"Drion G.","year":"2015","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_10_33_1","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s002340050648","article-title":"Focal Seizure\u2010Induced Premature Myelination: Speculation From Serial MRI","volume":"40","author":"Duprez T.","year":"1998","journal-title":"Neuroradiology"},{"key":"e_1_2_10_34_1","doi-asserted-by":"crossref","first-page":"11832","DOI":"10.1073\/pnas.1811013115","article-title":"Regulation of Myelin Structure and Conduction Velocity by Perinodal Astrocytes","volume":"115","author":"Dutta D. J.","year":"2018","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_10_35_1","doi-asserted-by":"crossref","first-page":"6937","DOI":"10.1523\/JNEUROSCI.0908-16.2016","article-title":"Dynamic\u00a0Modulation of Myelination in Response to Visual Stimuli Alters Optic Nerve Conduction Velocity","volume":"36","author":"Etxeberria A.","year":"2016","journal-title":"Journal of Neuroscience"},{"key":"e_1_2_10_36_1","doi-asserted-by":"crossref","first-page":"7267","DOI":"10.1523\/JNEUROSCI.17-19-07267.1997","article-title":"Conduction in Segmentally Demyelinated Mammalian Central Axons","volume":"17","author":"Felts P. A.","year":"1997","journal-title":"Journal of Neuroscience"},{"key":"e_1_2_10_37_1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1152\/jn.00317.2001","article-title":"Comparison of Cortico\u2010Cortical and Cortico\u2010Collicular Signals for the Generation of Saccadic Eye Movements","volume":"87","author":"Ferraina S.","year":"2002","journal-title":"Journal of Neurophysiology"},{"key":"e_1_2_10_38_1","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nrn4023","article-title":"A New Mechanism of Nervous System Plasticity: Activity\u2010Dependent Myelination","volume":"16","author":"Fields R. D.","year":"2015","journal-title":"Nature Reviews. Neuroscience"},{"key":"e_1_2_10_39_1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/s41593-020-0606-x","article-title":"Myelin makes memories","volume":"23","author":"Fields R. D.","year":"2020","journal-title":"Nature Neuroscience"},{"key":"e_1_2_10_40_1","doi-asserted-by":"crossref","first-page":"8073","DOI":"10.1038\/ncomms9073","article-title":"Tuning of Ranvier Node and Internode Properties in Myelinated Axons to Adjust Action Potential Timing","volume":"6","author":"Ford M. C.","year":"2015","journal-title":"Nature Communications"},{"key":"e_1_2_10_41_1","first-page":"E321","article-title":"Acceleration of Conduction Velocity Linked to Clustering of Nodal Components Precedes Myelination","volume":"112","author":"Freeman S. A.","year":"2015","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_10_42_1","doi-asserted-by":"crossref","first-page":"4855","DOI":"10.1113\/JP271369","article-title":"Homeostatic Regulation of h\u2010Conductance Controls Intrinsic Excitability and Stabilizes the Threshold for Synaptic Modification in CA1 Neurons","volume":"593","author":"Gasselin C.","year":"2015","journal-title":"Journal of Physiology"},{"key":"e_1_2_10_43_1","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511815706","volume-title":"Spiking Neuron Models: Single Neurons, Populations, Plasticity","author":"Gerstner W.","year":"2002"},{"key":"e_1_2_10_44_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/dneu.22541","article-title":"Bad Wrap: Myelin and Myelin Plasticity in Health and Disease","volume":"78","author":"Gibson E. M.","year":"2018","journal-title":"Developmental Neurobiology"},{"key":"e_1_2_10_45_1","doi-asserted-by":"crossref","DOI":"10.1126\/science.1252304","article-title":"Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain","volume":"344","author":"Gibson E. M.","year":"2014","journal-title":"Science"},{"key":"e_1_2_10_46_1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev-neuro-092920-121538","article-title":"Ion Channel Degeneracy, Variability, and Covariation in Neuron and Circuit Resilience","volume":"44","author":"Goaillard J.\u2010M.","year":"2021","journal-title":"Annual Review of Neuroscience"},{"key":"e_1_2_10_47_1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.yebeh.2011.06.025","article-title":"Accelerated Myelination With Motor System Involvement in a Neonate With Immediate Postnatal Onset of Seizures and Hemimegalencephaly","volume":"22","author":"Goldsberry G.","year":"2011","journal-title":"Epilepsy & Behavior"},{"key":"e_1_2_10_48_1","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1038\/nature09160","article-title":"Activity\u2010Dependent Relocation of the Axon Initial Segment Fine\u2010Tunes Neuronal Excitability","volume":"465","author":"Grubb M. S.","year":"2010","journal-title":"Nature"},{"key":"e_1_2_10_49_1","doi-asserted-by":"crossref","first-page":"7272","DOI":"10.1523\/JNEUROSCI.4747-14.2015","article-title":"Myelin Loss and Axonal Ion Channel Adaptations Associated With Gray Matter Neuronal Hyperexcitability","volume":"35","author":"Hamada M. S.","year":"2015","journal-title":"Journal of Neuroscience"},{"key":"e_1_2_10_50_1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.neuron.2013.08.038","article-title":"Firing Rate Homeostasis in Visual Cortex of Freely Behaving Rodents","volume":"80","author":"Hengen K. B.","year":"2013","journal-title":"Neuron"},{"key":"e_1_2_10_51_1","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2218841120","article-title":"Intrinsic Neural Diversity Quenches the Dynamic Volatility of Neural Networks","volume":"120","author":"Hutt A.","year":"2023","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_10_52_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1162\/089976606775093882","article-title":"Polychronization: Computation With Spikes","volume":"18","author":"Izhikevich E. M.","year":"2006","journal-title":"Neural Computation"},{"key":"e_1_2_10_53_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-66157-1","article-title":"Layer 5 Myelination Gates Corticothalamic Coincidence Detection","volume":"16","author":"Jamann N.","year":"2025","journal-title":"Nature Communications"},{"key":"e_1_2_10_54_1","first-page":"125","article-title":"Spike\u2010Based Compared to Rate\u2010Based Hebbian Learning","volume":"11","author":"Kempter R.","year":"1998","journal-title":"Advances in Neural Information Processing Systems"},{"key":"e_1_2_10_55_1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/s41582-022-00737-3","article-title":"Adaptive and Maladaptive Myelination in Health and Disease","volume":"18","author":"Knowles J. K.","year":"2022","journal-title":"Nature Reviews. Neurology"},{"key":"e_1_2_10_56_1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/s41593-022-01052-2","article-title":"Maladaptive Myelination Promotes Generalized Epilepsy Progression","volume":"25","author":"Knowles J. K.","year":"2022","journal-title":"Nature Neuroscience"},{"key":"e_1_2_10_57_1","doi-asserted-by":"crossref","DOI":"10.3389\/neuro.10.009.2009","article-title":"Made\u2010To\u2010Order Spiking Neuron Model Equipped With a Multi\u2010Timescale Adaptive Threshold","volume":"3","author":"Kobayashi R.","year":"2009","journal-title":"Frontiers in Computational Neuroscience"},{"key":"e_1_2_10_58_1","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s11357-011-9357-7","article-title":"Age\u2010Related Changes in Human and Non\u2010Human Primate White Matter: From Myelination Disturbances to Cognitive Decline","volume":"34","author":"Kohama S. G.","year":"2012","journal-title":"Age"},{"key":"e_1_2_10_59_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/978-3-642-97171-6_6","article-title":"Asymmetrically Diluted Neural Networks","author":"Kree R.","year":"1991","journal-title":"Models Neural Network"},{"key":"e_1_2_10_60_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10827-008-0135-1","article-title":"Correlations in Spiking Neuronal Networks With Distance Dependent Connections","volume":"27","author":"Kriener B.","year":"2009","journal-title":"Journal of Computational Neuroscience"},{"key":"e_1_2_10_61_1","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/nature09087","article-title":"Presynaptic Activity Regulates Na\u2009+\u2009Channel Distribution at the Axon Initial Segment","volume":"465","author":"Kuba H.","year":"2010","journal-title":"Nature"},{"key":"e_1_2_10_62_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2023.120312","article-title":"Quantitative MRI Reveals Widespread, Network\u2010Specific Myelination Change During Generalized Epilepsy Progression","volume":"280","author":"Kung G. C. L.","year":"2023","journal-title":"NeuroImage"},{"key":"e_1_2_10_63_1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0022-5193(84)80136-8","article-title":"On Approximations of Stein's Neuronal Model","volume":"107","author":"L\u00e1nsk\u1ef3 P.","year":"1984","journal-title":"Journal of Theoretical Biology"},{"key":"e_1_2_10_64_1","doi-asserted-by":"crossref","unstructured":"Lefebvre J. andA.Clappison.2024.\u201cDelay\u2010Induced Gain Control in Nonlinear Neural Networks.\u201d","DOI":"10.1038\/s42005-025-02055-8"},{"key":"e_1_2_10_65_1","doi-asserted-by":"crossref","DOI":"10.1038\/s42005-025-02055-8","article-title":"Myelin\u2010Induced Gain Control in Nonlinear Neural Networks","volume":"8","author":"Lefebvre J.","year":"2025","journal-title":"Communications on Physics"},{"key":"e_1_2_10_66_1","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.01849","article-title":"Dendritic and Axonal Propagation Delays May Shape Neuronal Networks With Plastic Synapses","volume":"9","author":"Madadi Asl M.","year":"2018","journal-title":"Frontiers in Physiology"},{"key":"e_1_2_10_67_1","doi-asserted-by":"crossref","first-page":"106308","DOI":"10.1063\/1.5037309","article-title":"Propagation Delays Determine Neuronal Activity and Synaptic Connectivity Patterns Emerging in Plastic Neuronal Networks","volume":"28","author":"Madadi Asl M.","year":"2018","journal-title":"Chaos Interdiscip. Journal of Nonlinear Science"},{"key":"e_1_2_10_68_1","doi-asserted-by":"crossref","first-page":"9099","DOI":"10.1523\/JNEUROSCI.0842-21.2021","article-title":"CNS Hypomyelination Disrupts Axonal Conduction and Behavior in Larval Zebrafish","volume":"41","author":"Madden M. E.","year":"2021","journal-title":"Journal of Neuroscience"},{"key":"e_1_2_10_69_1","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1007\/s00429-021-02358-w","article-title":"Dissecting Whole\u2010Brain Conduction Delays Through MRI Microstructural Measures","volume":"226","author":"Mancini M.","year":"2021","journal-title":"Brain Structure & Function"},{"key":"e_1_2_10_70_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017255","article-title":"Emergence of Resonances in Neural Systems: The Interplay Between Adaptive Threshold and Short\u2010Term Synaptic Plasticity","volume":"6","author":"Mejias J. F.","year":"2011","journal-title":"PLoS One"},{"key":"e_1_2_10_71_1","doi-asserted-by":"crossref","first-page":"ENEURO.0297","DOI":"10.1523\/ENEURO.0297-18.2018","article-title":"Distinctive Structural and Molecular Features of Myelinated Inhibitory Axons in Human Neocortex","volume":"5","author":"Micheva K. D.","year":"2018","journal-title":"Eneuro"},{"key":"e_1_2_10_72_1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.neuron.2017.07.009","article-title":"Wrapped to Adapt: Experience\u2010Dependent Myelination","volume":"95","author":"Mount C. W.","year":"2017","journal-title":"Neuron"},{"key":"e_1_2_10_73_1","doi-asserted-by":"crossref","first-page":"7348","DOI":"10.1073\/pnas.1131895100","article-title":"Decoding Neuronal Spike Trains: How Important Are Correlations?","volume":"100","author":"Nirenberg S.","year":"2003","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"e_1_2_10_74_1","doi-asserted-by":"crossref","first-page":"13227","DOI":"10.1073\/pnas.1916646117","article-title":"Activity\u2010Dependent Myelination: A Glial Mechanism of Oscillatory Self\u2010Organization in Large\u2010Scale Brain Networks","volume":"117","author":"Noori R.","year":"2020","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_10_75_1","doi-asserted-by":"crossref","DOI":"10.4249\/scholarpedia.7467","article-title":"Balance of Excitation and Inhibition","volume":"4","author":"Okun M.","year":"2009","journal-title":"Scholarpedia"},{"key":"e_1_2_10_76_1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.neuron.2014.04.002","article-title":"Cell Types, Network Homeostasis, and Pathological Compensation From a Biologically Plausible Ion Channel Expression Model","volume":"82","author":"O'Leary T.","year":"2014","journal-title":"Neuron"},{"key":"e_1_2_10_77_1","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1038\/s41593-024-01642-2","article-title":"Dynamics of Mature Myelin","volume":"27","author":"Osso L. A.","year":"2024","journal-title":"Nature Neuroscience"},{"key":"e_1_2_10_78_1","doi-asserted-by":"crossref","first-page":"10234","DOI":"10.1523\/JNEUROSCI.1275-09.2009","article-title":"How Connectivity, Background Activity, and Synaptic Properties Shape the Cross\u2010Correlation Between Spike Trains","volume":"29","author":"Ostojic S.","year":"2009","journal-title":"Journal of Neuroscience"},{"key":"e_1_2_10_79_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.neuroscience.2013.11.007","article-title":"Role of Myelin Plasticity in Oscillations and Synchrony of Neuronal Activity","volume":"276","author":"Pajevic S.","year":"2014","journal-title":"Neuroscience"},{"key":"e_1_2_10_80_1","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.81982","article-title":"Oligodendrocyte\u2010Mediated Myelin Plasticity and Its Role in Neural Synchronization","volume":"12","author":"Pajevic S.","year":"2023","journal-title":"eLife"},{"key":"e_1_2_10_81_1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41593-019-0582-1","article-title":"Preservation of a Remote Fear Memory Requires New Myelin Formation","volume":"23","author":"Pan S.","year":"2020","journal-title":"Nature Neuroscience"},{"key":"e_1_2_10_82_1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00422-009-0304-y","article-title":"Role of Spike\u2010Frequency Adaptation in Shaping Neuronal Response to Dynamic Stimuli","volume":"100","author":"Peron S. P.","year":"2009","journal-title":"Biological Cybernetics"},{"key":"e_1_2_10_83_1","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1093\/brain\/awab088","article-title":"Myelin and Axon Pathology in Multiple Sclerosis Assessed by Myelin Water and Multi\u2010Shell Diffusion Imaging","volume":"144","author":"Rahmanzadeh R.","year":"2021","journal-title":"Brain"},{"key":"e_1_2_10_84_1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1179850","article-title":"The Asynchronous State in Cortical Circuits","volume":"327","author":"Renart A.","year":"2010","journal-title":"Science"},{"key":"e_1_2_10_85_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1162\/neco.2007.19.1.1","article-title":"Mean\u2010Driven and Fluctuation\u2010Driven Persistent Activity in Recurrent Networks","volume":"19","author":"Renart A.","year":"2007","journal-title":"Neural Computation"},{"key":"e_1_2_10_86_1","doi-asserted-by":"crossref","first-page":"16217","DOI":"10.1523\/JNEUROSCI.1677-11.2011","article-title":"On the Distribution of Firing Rates in Networks of Cortical Neurons","volume":"31","author":"Roxin A.","year":"2011","journal-title":"Journal of Neuroscience"},{"key":"e_1_2_10_87_1","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abg8411","article-title":"Excitatory\u2010Inhibitory Balance Modulates the Formation and Dynamics of Neuronal Assemblies in Cortical Networks","volume":"7","author":"Sadeh S.","year":"2021","journal-title":"Science Advances"},{"key":"e_1_2_10_88_1","doi-asserted-by":"crossref","first-page":"6174","DOI":"10.1073\/pnas.0937380100","article-title":"Change of Conduction Velocity by Regional Myelination Yields Constant Latency Irrespective of Distance Between Thalamus and Cortex","volume":"100","author":"Salami M.","year":"2003","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"e_1_2_10_89_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neuroscience.2013.06.047","article-title":"Regulation of Conduction Time Along Axons","volume":"276","author":"Seidl A. H.","year":"2014","journal-title":"Neuroscience"},{"key":"e_1_2_10_90_1","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1038\/s41598-018-20591-y","article-title":"Efficient Communication Dynamics on Macro\u2010Connectome, and the Propagation Speed","volume":"8","author":"Shimono M.","year":"2018","journal-title":"Scientific Reports"},{"key":"e_1_2_10_91_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.116763","article-title":"Dynamic Tractography: Integrating Cortico\u2010Cortical Evoked Potentials and Diffusion Imaging","volume":"215","author":"Silverstein B. H.","year":"2020","journal-title":"NeuroImage"},{"key":"e_1_2_10_92_1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.neuron.2019.10.013","article-title":"Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice","volume":"105","author":"Steadman P. E.","year":"2020","journal-title":"Neuron"},{"key":"e_1_2_10_93_1","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1093\/cercor\/10.7.684","article-title":"Myelination Defects and Neuronal Hyperexcitability in the Neocortex of Connexin 32\u2010Deficient Mice","volume":"10","author":"Sutor B.","year":"2000","journal-title":"Cerebral Cortex"},{"key":"e_1_2_10_94_1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/BF00235567","article-title":"Characteristics of Interhemispheric Impulse Conduction Between Prelunate Gyri of the Rhesus Monkey","volume":"33","author":"Swadlow H.","year":"1978","journal-title":"Experimental Brain Research"},{"key":"e_1_2_10_95_1","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1152\/jn.1990.63.6.1477","article-title":"Efferent Neurons and Suspected Interneurons in S\u20101 Forelimb Representation of the Awake Rabbit: Receptive Fields and Axonal Properties","volume":"63","author":"Swadlow H. A.","year":"1990","journal-title":"Journal of Neurophysiology"},{"key":"e_1_2_10_96_1","doi-asserted-by":"crossref","DOI":"10.4249\/scholarpedia.1451","article-title":"Axonal Conduction Delays","volume":"7","author":"Swadlow H. A.","year":"2012","journal-title":"Scholarpedia"},{"key":"e_1_2_10_97_1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s43588-022-00315-z","article-title":"Homeostatic Coordination and Up\u2010Regulation of Neural Activity by Activity\u2010Dependent Myelination","volume":"2","author":"Talidou A.","year":"2022","journal-title":"Nature Computational Science"},{"key":"e_1_2_10_98_1","doi-asserted-by":"crossref","first-page":"11959","DOI":"10.1523\/JNEUROSCI.3296-08.2008","article-title":"Maladaptive Homeostatic Plasticity in a Rodent Model of Central Pain Syndrome: Thalamic Hyperexcitability After Spinothalamic Tract Lesions","volume":"28","author":"Wang G.","year":"2008","journal-title":"Journal of Neuroscience"},{"key":"e_1_2_10_99_1","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2023.1184563","article-title":"Homeostatic Regulation of Neuronal Function: Importance of Degeneracy and Pleiotropy","volume":"17","author":"Yang J.","year":"2023","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"e_1_2_10_100_1","first-page":"1","article-title":"Neuron Class\u2013Specific Responses Govern Adaptive Myelin Remodeling in the Neocortex","volume":"370","author":"Yang S. M.","year":"2020","journal-title":"Science"}],"container-title":["Glia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.70231","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/glia.70231","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/glia.70231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:03:12Z","timestamp":1790766192000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/glia.70231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":99,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10.1002\/glia.70231"],"URL":"https:\/\/doi.org\/10.1002\/glia.70231","archive":["Portico"],"relation":{},"ISSN":["0894-1491","1098-1136"],"issn-type":[{"value":"0894-1491","type":"print"},{"value":"1098-1136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"2026-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70231"}}