{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:53:34Z","timestamp":1791291214780,"version":"4.3.0"},"reference-count":102,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The zebrafish telencephalon is an excellent model for adult neurogenesis under physiological and regenerative conditions, as many pathways regulating neural stem cell behavior are conserved with mammalian neurogenic niches. Resident radial glial cells (RGCs) serve as neural stem cells in the adult brain and are readily accessible in\u00a0vivo, because forebrain eversion repositions the ventricular zone to the dorsal surface. Recent studies have revealed substantial heterogeneity among RGCs, including activation\u2010primed cells and deeply quiescent states during homeostasis. Here, we first review the evidence that four mechanisms control quiescence in pallial RGCs: Notch3\u2010mediated lateral inhibition, the neuronal bone morphogenetic protein (BMP)\u2010Id1 axis, the nuclear receptor Nr2f1b, and the secreted factor Midkine\u2010a. The evidence supporting them is unequal, and we state its level for each before asking whether they act together. Notch\u2010mediated lateral inhibition and neuronal BMP\u2010Id1 signaling converge on\n                    <jats:italic>her4.1<\/jats:italic>\n                    , the clearest documented interaction among them, whereas Nr2f1b establishes a deeper dormancy program that resists Notch and BMP inhibition and protects a reserve stem cell pool. Midkine\u2010a is proposed to reinforce quiescence, pending functional validation. Finally, we propose as a hypothesis that these mechanisms act as partially redundant inputs whose relative contributions determine quiescence depth and vary along the antero\u2010posterior axis of the pallium. Together, these findings reframe quiescence as a spectrum of actively maintained conditions rather than a passive default state. These mechanisms are conserved across vertebrates, with implications for understanding why mammalian neural stem cell pools decline with age and injury.\n                  <\/jats:p>","DOI":"10.1002\/glia.70234","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:07:57Z","timestamp":1791288477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Control of Neural Stem Cell Quiescence in the Adult Zebrafish Telencephalon: Established Mechanisms and an Integrative Hypothesis"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9048-2010","authenticated-orcid":false,"given":"Mathilde","family":"Hoareau","sequence":"first","affiliation":[{"name":"Institute of Biological and Chemical Systems\u2010Biological Information Processing (IBCS\u2010BIP) Karlsruhe Institute of Technology (KIT)  Karlsruhe Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2032-518X","authenticated-orcid":false,"given":"Nicolas","family":"Diotel","sequence":"additional","affiliation":[{"name":"UMR 1188, Diab\u00e8te ath\u00e9rothrombose Th\u00e9rapies R\u00e9union Oc\u00e9an Indien (D\u00e9TROi) Universit\u00e9 de La R\u00e9union, INSERM  Saint\u2010Pierre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4411-5646","authenticated-orcid":false,"given":"Sepand","family":"Rastegar","sequence":"additional","affiliation":[{"name":"Institute of Biological and Chemical Systems\u2010Biological Information Processing (IBCS\u2010BIP) Karlsruhe Institute of Technology (KIT)  Karlsruhe Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4721\u201009.2010"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.03.023"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.095018"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2007.05.014"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.077"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa2729"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0455\u201012.2012"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22269"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.152520"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1688"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2018.01.004"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.941893"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20615"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6170\u201009.2010"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22599"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.17231"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.70345"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a018887"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibneur.2024.12.002"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4374\u201007.2008"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.03.090"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20100716\u20102990\u20101_17"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073384"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109775"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gep.2015.05.004"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2010.01.003"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.568930"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23733"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2012.04.003"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22492"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gep.2015.11.003"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.05.012"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.123018"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23347"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.03.010"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010genet\u2010111523\u2010101949"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749\u20108104\u20107\u201032"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/ede.12474"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a019018"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22757"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21012"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.5595.2"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.25542"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10020391"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17091411"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.03.040"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22481"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010024\u201006315\u20101"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.25619"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1074560"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12111"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23849"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0072\u201009.2009"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.09.088"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.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