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Our previous study has identified an IFN\u2010\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010responsive microglia phenotype in the brain after stroke. However, its role in white matter repair remains poorly understood. Herein, we find that extracellular vesicles derived from IFN\u2010\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010responsive microglia (IFN\u2010\n                    <jats:italic>\u03b3<\/jats:italic>\n                    EVs) are internalized by oligodendrocyte precursor cells (OPCs), leading to impaired OPCs proliferation, survival, and differentiation and reduced white matter repair in a murine transient middle cerebral artery occlusion (tMCAO) model. Mechanistically, miR\u20109\u20105p enrichment in IFN\u2010\n                    <jats:italic>\u03b3<\/jats:italic>\n                    EVs suppresses NEDD4 expression, a key regulator of myelination, leading to reduced OPCs maturation and white matter repair. Genetic interventions including miR\u20109\u20105p knockdown in IFN\u2010\n                    <jats:italic>\u03b3<\/jats:italic>\n                    EVs or NEDD4 overexpression in OPCs restore remyelination and functional recovery. Our findings demonstrate that IFN\u2010\n                    <jats:italic>\u03b3<\/jats:italic>\n                    EVs act as negative regulators of OPCs differentiation and remyelination following ischemic stroke via miR\u20109\u20105p\/NEDD4 pathway. Targeting this signaling axis may represent a novel therapeutic strategy to enhance remyelination and functional recovery after stroke.\n                  <\/jats:p>","DOI":"10.1002\/glia.70235","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:51:22Z","timestamp":1790052682000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>IFN<\/scp>\n                    \u2010\n                    <scp>\n                      <i>\u03b3<\/i>\n                    <\/scp>\n                    \u2010Responsive Microglia\u2010Derived Extracellular Vesicles Impair White Matter Repair After Stroke Through a\n                    <scp>miR<\/scp>\n                    \u20109\u20105p\/\n                    <scp>NEDD4<\/scp>\n                    \u2010Dependent 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