{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T09:35:18Z","timestamp":1793007318187,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Glia"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Obesity is increasingly recognized as a chronic inflammatory condition, often driven by prolonged high\u2010fat diet (HFD) consumption. Beyond causing metabolic dysregulation, obesity can disrupt immune\u2013brain communication, contributing to the development of emotional disorders. During the early stages of HFD exposure, proinflammatory cytokines such as interleukin\u20101\u03b2 (IL\u20101\u03b2), Tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), and IL\u20106 are markedly elevated, but their levels typically return to baseline over time. Despite this normalization, persistent neuroinflammation and gliosis are observed, suggesting that adaptive immune mediators may play a role in chronic neuropathology. In our study using male C57BL\/6 mice, 12 and 16\u2009weeks of HFD\u2010induced obesity increased plasma IL\u201017A levels, a key cytokine produced by CD4\n                    <jats:sup>+<\/jats:sup>\n                    T helper 17 (Th17) cells, and upregulated IL\u201017A mRNA expression in the hypothalamus. Peripheral administration of recombinant IL\u201017A via intraperitoneal (i.p.) injection every 2\u2009days for 4\u2009weeks induced depressive and anxiety\u2010like behaviors, accompanied by enhanced microgliosis in emotion\u2010related brain regions and infiltration of CD4\n                    <jats:sup>+<\/jats:sup>\n                    \/IL\u201017A\n                    <jats:sup>+<\/jats:sup>\n                    cells in the meninges. Peripheral IL\u201017A administration also reduced heart rate variability (HRV), accompanied by altered HRV\u2010derived indices, suggesting disruption of autonomic nervous system (ANS) regulation. Systemic administration of plasma derived from mice with 12\u2010week HFD\u2010induced obesity (OB plasma) evoked depressive and anxiety\u2010like phenotypes, as well as ANS dysfunction. Neutralizing anti\u2010IL\u201017A in the OB plasma effectively blocked these emotional and physiological impairments induced by OB plasma administration. Thus, our findings identify IL\u201017A as a critical mediator linking metabolic dysfunction, neuroinflammation, and emotional disorders, highlighting its potential as a therapeutic target for obesity\u2010associated depression and anxiety.\n                  <\/jats:p>","DOI":"10.1002\/glia.70237","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:40:31Z","timestamp":1790404831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interleukin\u201017A Links Obesity\u2010Induced Inflammation to\u00a0Behavioral Disorders and Autonomic Imbalance"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1634-1972","authenticated-orcid":false,"given":"Jing\u2010Ting","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Life Sciences, College of Bioscience and Biotechnology National Cheng Kung University  Tainan 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