{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:29:02Z","timestamp":1789504142060,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2004,11,3]],"date-time":"2004-11-03T00:00:00Z","timestamp":1099440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the neuropsychological performance associated with early and late onset Alzheimer's disease (AD), in order to identify differences and compare these with previous reports.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients attending a memory clinic were given a detailed multi\u2010disciplinary diagnostic assessment, including a battery of neuropsychological tests. From those meeting ICD\u201010 criteria for Alzheimer's disease (AD), an early\u2010onset (EO) group (<jats:italic>n<\/jats:italic>\u2009=\u200940) and a late\u2010onset (LO) group (<jats:italic>n<\/jats:italic>\u2009=\u200990) were identified, and their performances compared. Patients with mixed dementia and co\u2010morbid depression were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After adjustment, the EO and LO groups performed at a comparable level on the majority of the neuropsychological tests. The LO group performed better on the WAIS digit span test, AMIPB Complex Design and the written picture description, and the EO group performed better on the WAIS similarities test and the Boston naming test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that, after adjusting for overall dementia severity and pre\u2010morbid IQ, there is greater fronto\u2010parietal\/right hemisphere involvement in early\u2010onset AD, and greater temporal\/left hemisphere involvement in late\u2010onset AD. This may be due to different genetic risk profiles for AD at different ages. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.1196","type":"journal-article","created":{"date-parts":[[2004,11,5]],"date-time":"2004-11-05T14:38:07Z","timestamp":1099665487000},"page":"1140-1147","source":"Crossref","is-referenced-by-count":32,"title":["Neuropsychological performance in early and late onset Alzheimer's disease: comparisons in a memory clinic population"],"prefix":"10.1002","volume":"19","author":[{"given":"Srinivas","family":"Suribhatla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Baillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dennis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mangesh","family":"Marudkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saquib","family":"Muhammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dena","family":"Munro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Spreadbury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Lindesay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,11,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.887"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(85)90139-8"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1991.00530140047016"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520270037018"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520310107024"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.930060306"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.357"},{"key":"e_1_2_1_9_1","first-page":"93","article-title":"Relation of age at onset and duration of illness of cognitive functioning in Alzheimer's disease","volume":"2","author":"Brandt J","year":"1989","journal-title":"Neuropsychiat Neuropsychol Behav Neurology"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.2.321"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.4.416"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1984.04050230026012"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1986.00520060038014"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.9.1631"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-199809000-00007"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.3.484"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410030620"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(87)90118-7"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093-934X(91)90172-W"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.6.980"},{"key":"e_1_2_1_21_1","volume-title":"Cognitive Assessment for Clinicians","author":"Hodges JR","year":"1994"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.9.1601"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.7.1215"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.142.5.638"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.1.136"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.151.11.1646"},{"key":"e_1_2_1_27_1","volume-title":"Neuropsychological Assessment","author":"Lezak MD","year":"1995"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(85)90021-1"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1993.tb05947.x"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.5.1113"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.9.1689"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03589-3"},{"key":"e_1_2_1_34_1","volume-title":"National Adult Reading Test","author":"Nelson HE","year":"1982"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(78)80049-5"},{"key":"e_1_2_1_36_1","first-page":"75","article-title":"Boston Naming Test correlates with positron emission tomography in Alzheimer's Disease and normals","volume":"9","author":"Parks RW","year":"1987","journal-title":"J Clin Exp Neuropsychol"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-199500091-00002"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1994.00540240033012"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1996.00550100142023"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.149.6.698"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.47.1.387"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.12.1899"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1983.04050030037006"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.5.1.66"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540340047031"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-03-00994.2003"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.7.1154"},{"key":"e_1_2_1_48_1","volume-title":"The ICD\u201010 Classification of Mental and Behavioural Disorders","author":"World Health Organization","year":"1993"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgps.1196","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.1196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T11:13:48Z","timestamp":1700219628000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.1196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,3]]},"references-count":47,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1002\/gps.1196"],"URL":"https:\/\/doi.org\/10.1002\/gps.1196","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,3]]}}}