{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T06:28:43Z","timestamp":1769236123107,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,2,13]],"date-time":"2006-02-13T00:00:00Z","timestamp":1139788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The goal of this study was to examine the association between antidepressant use and hospitalization rate for mania or bipolar depression in a large, community\u2010based sample of elderly bipolar patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Population\u2010based retrospective cohort design. Administrative healthcare databases were linked for all individuals aged 66 years or older in the Province of Ontario, Canada. Bipolar subjects who received a prescription for an antidepressant medication (<jats:italic>n<\/jats:italic>\u2009=\u20091,072) between 1 April 1997 and 31 March 2001 comprised the antidepressant cohort. The control group (<jats:italic>n<\/jats:italic>\u2009=\u20093,000) consisted of randomly selected subjects from the eligible bipolar population who did not receive a prescription for an antidepressant medication during the same surveillance period. Primary outcomes were admission to hospital for a manic\/mixed or depressive episode.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a total of 5135 person\u2010years of follow up, 113 admissions for a manic\/mixed episode and 28 admissions for a depressive episode were identified. Model based estimates adjusted for a number of covariates revealed that, as compared with the control group, the antidepressant cohort had significantly lower likelihood of admissions for manic\/mixed (adjusted rate ratio [aRR]\u2009=\u20090.5, 95% CI\u2009=\u20090.3\u20130.8) but not depressive episodes (aRR\u2009=\u20090.7, 95% CI\u2009=\u20090.2\u20132.2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Antidepressant use among elderly bipolar patients was associated with decreased rates of hospitalization for manic\/mixed episodes. This finding requires confirmation with further data of antidepressant use among elderly bipolars. 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