{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:12:50Z","timestamp":1780067570734,"version":"3.54.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,9,5]],"date-time":"2006-09-05T00:00:00Z","timestamp":1157414400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is well\u2010established that the incidence of major depressive disorder is increased in subjects with subthreshold depression. A new research area focuses on the possibilities of preventing the onset of major depressive disorders in subjects with subthreshold depression. An important research question for this research area is which subjects with subthreshold depression will develop a full\u2010blown depressive disorder and which will not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We selected 154 older subjects with subthreshold depression (CES\u2010D\u2009&gt;\u200916) but no DSM mood disorder from a longitudinal study among a large population based cohort aged between 55 and 85 years in The Netherlands. Of these subjects, 31 (20.1%) developed a mood disorder (major depression and\/or dysthymia) at three\u2010year or six\u2010year follow\u2010up. We examined risk factors and individual symptoms of mood disorder as predictors of onset of mood disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two variables were found to be significant predictors in both bivariate and multivariate analyses: eating problems and sleep problems. The incidence of mood disorders differed strongly for different subpopulations, varying from 9% (for those not having any of the two risk factors) to 57% (for those having both risk factors).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It appears to be possible to predict to a certain degree whether a subject with subthreshold depression will develop a mood disorder during the following years. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.1565","type":"journal-article","created":{"date-parts":[[2006,9,5]],"date-time":"2006-09-05T18:33:49Z","timestamp":1157481229000},"page":"811-818","source":"Crossref","is-referenced-by-count":49,"title":["Predicting the onset of major depressive disorder and dysthymia in older adults with subthreshold depression: a community based study"],"prefix":"10.1002","volume":"21","author":[{"given":"Pim","family":"Cuijpers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aartjan","family":"Beekman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Smit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorly","family":"Deeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,5]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"95","article-title":"Screening for depression in the elderly in the community: using the Center for Epidemiologic Studies Depression scale (CES\u2010D) in the Netherlands","volume":"25","author":"Beekman ATF","year":"1994","journal-title":"Tijdschr Gerontol Geriatr"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(94)00103-G"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291796003510"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2002.10078.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114408"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03450190056028"},{"key":"e_1_2_1_8_1","volume-title":"Social Origins of Depression","author":"Brown GW","year":"1978"},{"key":"e_1_2_1_9_1","volume-title":"Health Interview Questionnaire","author":"Central Bureau of Statistics","year":"1989"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199503000-00016"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.12.1127"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.6.1147"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199403000-00006"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2004.00301.x"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(02)00348-8"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2004.00416.x"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.nmd.0000152810.76190.a6"},{"key":"e_1_2_1_18_1","unstructured":"DeegDJH KnipscheerCPM van TilburgW.1993.Autonomy and Well\u2010Being in the Aging Population: Concepts and Design of the Longitudinal Aging Study Amsterdam. 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