{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T03:44:29Z","timestamp":1775792669858,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,9,27]],"date-time":"2006-09-27T00:00:00Z","timestamp":1159315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Standard measurement scales used in anti\u2010dementia trials may not capture symptomatic changes recognized by clinicians and caregivers. We studied a symptom checklist, completed separately by caregivers and by clinicians, to identify patterns of change associated with donepezil treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a multi\u2010centre, 6\u2010month, open\u2010label study of 101 primary care patients, changes in a 19\u2010symptom checklist were assessed in relation to changes in standardized scales of cognition, activities of daily living, behavior, and caregiver burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three symptoms were reported in more than 80% of patients by both clinicians and caregivers: problems in remembering, (97%), temporal orientation (89%), and repetitiveness (85%). Five others overlapped on each of the clinician and caregiver \u2018top ten\u2019, including cognitive activation, spatial orientation, leisure, attention, and apathy. Clinicians reported that symptoms did not improve in 38 patients, whereas there was some improvement in 43, and improvement in most symptoms in 20. Caregivers reported that symptoms did not improve in 55 patients, whereas 27 and 19 patients showed some and most symptoms improving respectively. Patients with the greatest symptomatic improvement also improved most on the ADAS\u2010Cog and the other standardized measures, whereas no improvement (or decline) in each standardized measure was observed in people whose symptoms worsened or did not improve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A symptom checklist allowed clinically meaningful profiles to be identified, but revealed different estimates of response between clinicians and caregivers. Both agreed that improved executive function was the most common response. A symptom checklist can help translate between standard measures and everyday practice. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.1675","type":"journal-article","created":{"date-parts":[[2006,9,27]],"date-time":"2006-09-27T13:57:38Z","timestamp":1159365458000},"page":"312-319","source":"Crossref","is-referenced-by-count":16,"title":["Specific symptomatic changes following donepezil treatment of Alzheimer's disease: a multi\u2010centre, primary care, open\u2010label study"],"prefix":"10.1002","volume":"22","author":[{"given":"Kenneth","family":"Rockwood","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Black","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc\u2010Andre","family":"Bedard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thang","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Lussier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,27]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"21","article-title":"Comparing non\u2010independent proportions","volume":"3","author":"Berry JJ","year":"1994","journal-title":"Observations"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16499-4"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.12.2308"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199710)12:10<978::AID-GPS659>3.0.CO;2-1"},{"key":"e_1_2_1_6_1","first-page":"235","volume-title":"Research Advances in Alzheimer's Disease and Related Disorders","author":"Feldman H","year":"1995"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.5014\/ajot.53.5.471"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.060261"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.331.7512.321"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01530764"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/089198879600900404"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.733"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.73.5.500"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1188"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.051432"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.141.11.1356"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17670-8"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.14.4.377"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.2307\/2682774"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000079202"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.2307\/2684972"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.496"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgps.1675","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.1675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T19:54:10Z","timestamp":1700078050000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.1675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,27]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1002\/gps.1675"],"URL":"https:\/\/doi.org\/10.1002\/gps.1675","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,27]]}}}