{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:46:36Z","timestamp":1791229596912,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,3,8]],"date-time":"2007-03-08T00:00:00Z","timestamp":1173312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>When comparing with early\u2010onset Alzheimer's disease (EO\u2010AD) and late\u2010onset Alzheimer's disease (LO\u2010AD), some symptomatological differences in clinical features can be seen between them. Rapid progression, more severe language problems or visuospatial dysfunction occur more often in EO\u2010AD patients. However, there have been very few reports about the differences in behavioral and psychological symptoms between these two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to demonstrate the differences in behavioral symptoms between EO\u2010AD and LO\u2010AD groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Three hundred and seven consecutive outpatients with AD were put into an EO\u2010AD group (46 patients) or a LO\u2010AD group (261 patients). Comprehensive assessment batteries, including the Neuropsychiatric Inventory (NPI), were administered at the first medical assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant differences were found between the EO\u2010AD and LO\u2010AD groups in terms of NPI total score (EO\u2010AD: 10.3\u2009\u00b1\u200910.9, LO\u2010AD: 17.8\u2009\u00b1\u200917.0, <jats:italic>p<\/jats:italic>\u2009=\u20090.004) and number of patients who experienced each NPI subscale score (delusion; EO\u2010AD: 13.0%, LO\u2010AD: 50.6%, <jats:italic>p<\/jats:italic>\u2009<jats:italic>&lt;<\/jats:italic>\u20090.001). There were no differences in cognitive functions or dementia severity between two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In EO\u2010AD, behavioral and psychological symptoms are relatively fewer than LO\u2010AD at the first medical assessment. 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