{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:15:40Z","timestamp":1791357340887,"version":"4.3.1"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,2,23]],"date-time":"2007-02-23T00:00:00Z","timestamp":1172188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies have evaluated medication adherence among older <jats:italic>vs<\/jats:italic> younger individuals with bipolar disorder (BPD). We compared adherence with antipsychotic medication among older (age 60 and older) and younger individuals using a large case registry (<jats:italic>n<\/jats:italic>\u2009=\u200973,964).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adherence was evaluated using the medication possession ratio (MPR) for patients receiving antipsychotic medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty six thousand five hundred and thirty younger individuals (mean age 46.9) and 6,461 older individuals (mean age 69.2) were prescribed antipsychotic medication. Among older individuals, 61.0% (<jats:italic>n<\/jats:italic>\u2009=\u20093,350) were fully adherent, while 19.0% (<jats:italic>n<\/jats:italic>\u2009=\u20091,043) were partially adherent and 20.0% (<jats:italic>n<\/jats:italic>\u2009=\u20091,098) were non\u2010adherent. Among younger individuals, 49.5% (<jats:italic>n<\/jats:italic>\u2009=\u200910,644) were fully adherent, while 21.8% (<jats:italic>n<\/jats:italic>\u2009=\u20094,680) were partially adherent, and 28.7% (<jats:italic>n<\/jats:italic>\u2009=\u20096,170) were non\u2010adherent. As with younger patients, comorbid substance abuse and homelessness predicted non\u2010adherence among older patients with BPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Older individuals with BPD were more adherent with antipsychotic medications compared to younger individuals. However, a substantial proportion (approximately 39%) of older patients with BPD still have difficulties with adherence. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.1777","type":"journal-article","created":{"date-parts":[[2007,2,23]],"date-time":"2007-02-23T19:15:54Z","timestamp":1172258154000},"page":"992-998","source":"Crossref","is-referenced-by-count":45,"title":["Age comparison of treatment adherence with antipsychotic medications among individuals with bipolar disorder"],"prefix":"10.1002","volume":"22","author":[{"given":"Martha","family":"Sajatovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic C.","family":"Blow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen C.","family":"Kales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"Valenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dara","family":"Ganoczy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalinda V.","family":"Ignacio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,2,23]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1014670"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(90)90077-L"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079903125002270"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2004.00154.x"},{"key":"e_1_2_1_6_1","first-page":"49","article-title":"Treatment adherence in bipolar patients","volume":"1","author":"Colom F","year":"2002","journal-title":"Clin Approaches Bipolar Disord"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0208"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.4.692"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2005.07.009"},{"key":"e_1_2_1_10_1","first-page":"87","article-title":"Compliance with maintenance treatment in bipolar disorder","volume":"33","author":"Keck PE","year":"1997","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2002.1r084.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.03.013"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.2005.25.9.1242"},{"key":"e_1_2_1_14_1","first-page":"56","article-title":"Medication non\u2010adherence in bipolar disorder: a patient centered review of research findings","volume":"3","author":"Perlick DA","year":"2004","journal-title":"Clin Approaches Bipolar Disord"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.02.016"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.57.1.56"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.2005.25.7.909"},{"key":"e_1_2_1_18_1","first-page":"319","article-title":"What do patients in a lithium outpatient clinic know about lithium therapy?","volume":"26","author":"Schaub RT","year":"2001","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2002.02242.x"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-200208000-00002"},{"key":"e_1_2_1_21_1","volume-title":"Bipolar Disorders in Later Life","author":"Valenstein M"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2005.12.042"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2005.00041.x"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgps.1777","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.1777","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T11:08:08Z","timestamp":1699960088000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.1777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,23]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1002\/gps.1777"],"URL":"https:\/\/doi.org\/10.1002\/gps.1777","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2,23]]}}}