{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:00:52Z","timestamp":1790866852509,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,6,11]],"date-time":"2007-06-11T00:00:00Z","timestamp":1181520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Depression occurs frequently in patients with both Alzheimer's disease (AD) and Parkinson's disease (PD), but there has been little comparison of depression symptoms in the two populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The 15\u2010item Geriatric Depression Scale (GDS\u201015) was administered as a depression screening instrument to 232\u2009AD patients and 266\u2009PD specialty care patients with at most mild dementia. Logistic regression models were used to determine disease\u2010specific associations with individual GDS\u201015 items, and factor analysis was used to assess GDS\u201015 factor structure in the two populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Controlling for total GDS\u201015 score and other covariates, AD patients reported more dissatisfaction with life (<jats:italic>p<\/jats:italic>\u2009=\u20090.03) and memory problems (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), while PD patients reported more fearfulness (<jats:italic>p<\/jats:italic>\u2009=\u20090.01), helplessness (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), a preference to stay at home (<jats:italic>p<\/jats:italic>\u2009=\u20090.02), and diminished energy (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Three factors were generated in PD (explaining 55% of the total variance) and five in AD (explaining 59% of the total variance), and the two main factors generated in both populations related primarily to unhappiness and negative thoughts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The factor structure of the GDS\u201015 is similar in AD and PD patients with at most mild stage dementia, but between\u2010group differences on 6 of the GDS\u201015 items suggests the non\u2010specificity of certain items in the two populations. 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