{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:33:40Z","timestamp":1791063220638,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,2,11]],"date-time":"2009-02-11T00:00:00Z","timestamp":1234310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We previously found that the polymorphisms of cholesterol 24\u2010hydroxylase (CYP46A1) gene were associated with the risk of Alzheimer's disease (AD) in Chinese. However, its effect in predicting progression of cognitive decline remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and eighty\u2010one Chinese subjects (121 cognitively intact, 101 with mild cognitive impairment and 59 with mildly dementia) were followed\u2010up with a mean (SD) duration of 25.22(5.74) months. Association between the CYP46A1 gene polymorphisms and 2\u2010year cognitive deterioration were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At follow\u2010up, 225(80.0%) subjects were reassessed. Sixty\u2010three subjects were diagnosed as AD, 68 were MCI and 94 were cognitively intact. Among them, 158 had improved or remained stable while 67 deteriorated. The \u2018deteriorated\u2019 group was older than \u2018improved or stable\u2019 group (<jats:italic>t<\/jats:italic>\u2010test, <jats:italic>t<\/jats:italic>\u2009=\u2009\u22122.87, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). IVS2\u2010150 polymorphism was associated with a higher risk of cognitive deterioration. Subjects with T allele were more likely to deteriorate compared with those without T allele (Pearson <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20098.98, df 2, <jats:italic>p<\/jats:italic>\u2009<jats:italic>=<\/jats:italic>\u20090.011). IVS3\u2010128 CC genotype was higher in \u2018improved or stable\u2019 group (Likelihood Ratio\u2009=\u20096.55, df 2, <jats:italic>p<\/jats:italic>\u2009<jats:italic>=<\/jats:italic>\u20090.038), suggesting a protective role for this allele. The two other polymorphisms, IVS1\u2010192 and IVS4\u2010122, did not show any significant association with cognitive function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CYP46A1 gene may act to modulate the course of cognitive deterioration in late life. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.2196","type":"journal-article","created":{"date-parts":[[2009,2,11]],"date-time":"2009-02-11T09:17:58Z","timestamp":1234343878000},"page":"921-926","source":"Crossref","is-referenced-by-count":27,"title":["Cholesterol 24\u2010hydroxylase (CYP46A1) polymorphisms are associated with faster cognitive deterioration in Chinese older persons: a two\u2010year follow up study"],"prefix":"10.1002","volume":"24","author":[{"given":"Brenda Yan","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk Ling","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson Leung Sang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy Woon 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