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We predicted that duloxetine pharmacotherapy and Depression and Pain Care Management (DPCM) would result in (1) significant improvement in MDD and CLBP and (2) significant improvements in health\u2010related quality of life, anxiety, disability, self\u2010efficacy, and sleep quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Intervention<\/jats:title><jats:p>Twelve week open\u2010label study using duloxetine up to 120\u2009mg\/day\u2009+\u2009DPCM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Outpatient late\u2010life depression research clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Thirty community\u2010dwelling adults <jats:styled-content>&gt;<\/jats:styled-content>60 years old.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome Measures<\/jats:title><jats:p>Montgomery Asberg Depression Rating Scale (MADRS) and McGill Pain Questionnaire\u2010Short Form (MPQ\u2010SF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>46.7% (<jats:italic>n<\/jats:italic>\u2009=\u200914) of the sample had a depression remission. All subjects who met criteria for the depression remission also had a pain response. 93.3% (<jats:italic>n<\/jats:italic>\u2009=\u200928) had a significant pain response. Of the subjects who met criteria for a low back pain response, 50% (<jats:italic>n<\/jats:italic>\u2009=\u200914) also met criteria for the depression remission. The mean time to depression remission was 7.6 (SE\u2009=\u20090.6) weeks. The mean time to pain response was 2.8 (SE\u2009=\u20090.5) weeks. There were significant improvements in mental health\u2010related quality of life, anxiety, sleep quality, somatic complaints, and both self\u2010efficacy for pain management and for coping with symptoms. Physical health\u2010related quality of life, back pain\u2010related disability, and self\u2010efficacy for physical functioning did not improve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serotonin and norepinephrine reuptake inhibitors like duloxetine delivered with DPCM may be a good choice to treat these linked conditions in older adults. Treatments that target low self\u2010efficacy for physical function and improving disability may further increase response rates. 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