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Holotranscobalamin is a novel, more accurate measure of tissue vitamin B12.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine associations between vitamin B12, serum folate, holotranscobalamin, homocysteine and depressive symptoms in a sample of healthy elderly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional, observational community based study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lower levels of holotranscobalamin and vitamin B12 were associated with higher levels of depressive symptoms when controlled for Mini\u2010mental state examination scores and psychosocial and cardiovascular risk factors. Homocysteine was not associated with depressive symptoms when biological and psychosocial covariates were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It is possible that low levels of vitamin B12 or holotranscobalamin are associated with depressive symptoms via mechanisms other than vascular pathology.<\/jats:p><jats:p>Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.2530","type":"journal-article","created":{"date-parts":[[2010,7,12]],"date-time":"2010-07-12T04:30:37Z","timestamp":1278909037000},"page":"307-313","source":"Crossref","is-referenced-by-count":23,"title":["Associations between holotranscobalamin, vitamin B12, homocysteine and depressive symptoms in community\u2010dwelling elders"],"prefix":"10.1002","volume":"26","author":[{"given":"DJ","family":"Robinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"O'Luanaigh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Tehee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"O'Connell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AV","family":"Chin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Coen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AM","family":"Molloy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CJ","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BA","family":"Lawlor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1997.01830220033006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1255"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.6.618"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/58.3.M249"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.027458"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/clinchem\/48.3.407","article-title":"Measuring and interpreting holo\u2010transcobalamin (holo\u2010transcobalamin II)","volume":"48","author":"Carmel R","year":"2002","journal-title":"Clin Chem"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afn144"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(99)00151-1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881105048899"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.149286"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)03383-8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.6.861"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199905)14:5<331::AID-GPS911>3.0.CO;2-8"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(03)00169-1"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2005.130"},{"key":"e_1_2_9_18_1","unstructured":"InstituteSAS.2007.JMP7.0.2 ed. 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