{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:07:01Z","timestamp":1770275221906,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T00:00:00Z","timestamp":1288310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nilvadipine may lower rates of conversion from mild\u2010cognitive impairment to Alzheimer's disease (AD), in hypertensive patients. However, it remains to be determined whether treatment with nilvadipine is safe in AD patients, given the higher incidence of orthostatic hypotension (OH) in this population, who may be more likely to suffer from symptoms associated with the further exaggeration of a drop in BP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to investigate the safety and tolerability of nilvadipine in AD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>AD patients in the intervention group (n\u2009=\u200956) received nilvadipine 8\u2009mg daily over 6\u2010weeks, compared to the control group (n\u2009=\u200930) who received no intervention. Differences in systolic (SBP) and diastolic (DBP) blood pressure, before and after intervention, was assessed using automated sphygmomanometer readings and ambulatory BP monitors (ABP), and change in OH using a finometer. Reporting of adverse events was monitored throughout the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant reduction in the SBP of treated patients compared to non\u2010treated patients but no significant change in DBP. Individuals with higher initial blood pressure (BP) had greater reduction in BP but individuals with normal BP did not experience much change in their BP. While OH was present in 84% of the patients, there was no further drop in BP recorded on active stand studies. There were no significant differences in adverse event reporting between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Nilvadipine was well tolerated by patients with AD. This study supports further investigation of its efficacy as a potential treatment for AD. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.2638","type":"journal-article","created":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T12:24:43Z","timestamp":1288355083000},"page":"1038-1045","source":"Crossref","is-referenced-by-count":28,"title":["Demonstration of safety in Alzheimer's patients for intervention with an anti\u2010hypertensive drug Nilvadipine: results from a 6\u2010week open label study"],"prefix":"10.1002","volume":"26","author":[{"given":"S. P.","family":"Kennelly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Paris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Parish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Mathura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mullan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. A.","family":"Lawlor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Kenny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,10,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.102343"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1861"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1991.tb02869.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.70.827.638"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152709787847270"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90128-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03029744"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000122962"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199212071-00009"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67889-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)03086-4"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.18.2046"},{"key":"e_1_2_7_15_1","first-page":"711","article-title":"Clinic and 24h blood pressure in elderly treated hypertensives with postural hypotension","volume":"8","author":"Fotherby MD","year":"1994","journal-title":"J Hum Hypertens"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1851"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.09.28"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199212071-00007"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079905X48438"},{"key":"e_1_2_7_20_1","first-page":"D000147","article-title":"Nimodipine for primary degenerative, mixed and vascular dementia","author":"Lopez\u2010Arrieta JM","year":"2002","journal-title":"Cochrane Database Syst Rev C"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050479"},{"key":"e_1_2_7_22_1","first-page":"501","article-title":"Calcium\u2010channel blockers and cognitive function in elderly people: results from the canadian study of health and aging","volume":"161","author":"Maxwell CJ","year":"1999","journal-title":"CMAJ"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(97)00485-8"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7242.1128"},{"key":"e_1_2_7_26_1","first-page":"255","article-title":"Validation of the A&D TM\u20102430 device for ambulatory blood pressure monitoring and evaluation of performance according to subjects' characteristics","volume":"3","author":"Palatini P","year":"1998","journal-title":"Blood Press Monit"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-7061(95)00341-X"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988703252558"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2009.04.1233"},{"key":"e_1_2_7_30_1","first-page":"32","article-title":"The cerebral circulation in the elderly: the influence of age, vascular disease, and antihypertensive treatment","volume":"2","author":"Strandgaard S","year":"1993","journal-title":"Am J Geriatr Cardiol"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90894-D"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.10.006"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(97)00881-3"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0b013e3280b083bd"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1990.tb03481.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.5.1470"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2004.03.009"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgps.2638","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.2638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T15:28:53Z","timestamp":1697642933000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.2638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,29]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1002\/gps.2638"],"URL":"https:\/\/doi.org\/10.1002\/gps.2638","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,29]]}}}