{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:17:25Z","timestamp":1790183845087,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T00:00:00Z","timestamp":1301443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to evaluate the differential predictive values of age, age of onset and duration of illness on paroxetine and cognitive\u2010behavioural therapy (CBT) outcome in late\u2010life panic disorder with agoraphobia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients 60\u2009years and older with a confirmed diagnosis of panic disorder with agoraphobia (<jats:italic>n<\/jats:italic>\u2009=\u200949) were randomly assigned to paroxetine (40\u2009mg\/day) treatment, individual CBT or a waiting\u2010list control condition. Multiple regression analyses were conducted per treatment arm with post\u2010treatment avoidance behaviour and agoraphobic cognitions as the dependent variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher age at onset and shorter duration of illness were predictors of superior outcomes following CBT, although these variables did not influence the treatment effects of paroxetine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In late\u2010life agoraphobic panic disorder, chronological age has no impact on treatment modality outcome. In older patients with a late disease onset or shorter duration of illness, CBT is to be preferred over paroxetine, whereas paroxetine might be the treatment of choice for older people with an early onset and short duration of illness. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.2700","type":"journal-article","created":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T11:12:29Z","timestamp":1301483549000},"page":"146-150","source":"Crossref","is-referenced-by-count":29,"title":["Predictors of outcome of pharmacological and psychological treatment of late\u2010life panic disorder with agoraphobia"],"prefix":"10.1002","volume":"27","author":[{"given":"Gert\u2010Jan","family":"Hendriks","sequence":"first","affiliation":[{"name":"Centre for Anxiety Disorders \u201cOverwaal\u201d  Lent the Netherlands"},{"name":"Behavioral Science Institute Radboud University Nijmegen  Nijmegen the Netherlands"},{"name":"Department of Psychiatry (966) Radboud University Nijmegen Medical Centre  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ger P. J.","family":"Keijsers","sequence":"additional","affiliation":[{"name":"Behavioral Science Institute Radboud University Nijmegen  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Kampman","sequence":"additional","affiliation":[{"name":"Centre for Anxiety Disorders \u201cOverwaal\u201d  Lent the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cees A. L.","family":"Hoogduin","sequence":"additional","affiliation":[{"name":"Behavioral Science Institute Radboud University Nijmegen  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C.","family":"Oude Voshaar","sequence":"additional","affiliation":[{"name":"University Centre of Psychiatry University Medical Centre Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(94)90040-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.52.6.1090"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(85)90140-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.128.3.280"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.71.1.31"},{"key":"e_1_2_7_7_1","volume-title":"Anxiety Disorders Interview Schedule for DSM\u2010IV: Lifetime Version","author":"DiNardo PA","year":"1994"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291707000682"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291707000670"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525\u20101497.2005.00296.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100447.2009.01517.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1352465807004018"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.593"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.9.1588"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e31806841c8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/16506070410031691"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.JGP.0000196629.19634.00"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(99)00082-8"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291798007119"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2190\/KQEJ-MQJR-VK3D-F3HV"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1176\/appi.ajgp.12.2.230","article-title":"Efficacy of sertraline for panic disorder in older adults: a preliminary open\u2010label trial","volume":"12","author":"Sheikh JI","year":"2004","journal-title":"Am J Geriatr Psychiatry"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.1053"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/00019442-199600410-00006","article-title":"Cognitive\u2010behavioral therapy in older panic disorder patients","volume":"1","author":"Swales PJ","year":"1996","journal-title":"Am J Geriatr Psychiatry"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291704002569"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2190\/QA7Y-TX1Y-WM45-KGV7"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-7894(05)80063-2"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgps.2700","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.2700","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T12:09:26Z","timestamp":1700568566000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.2700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,30]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1002\/gps.2700"],"URL":"https:\/\/doi.org\/10.1002\/gps.2700","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,30]]}}}