{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:22:01Z","timestamp":1789748521359,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,4,2]],"date-time":"2011-04-02T00:00:00Z","timestamp":1301702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The neuropsychiatric complications of Parkinson's disease (PD), which include behaviour disturbances such as apathy and the impulse control disorders (ICDs), may have a significant effect on patients with PD and their carers. The contribution of these behaviour disorders to carer burden is less understood. Therefore, the aim of this study was to explore the relationship that apathy and ICDs have with carer burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Non\u2010demented (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200971) PD\u2013carer dyads (spouse or adult child) participated in the study. The PD participants were divided into three behavioural groups: ICD (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921), apathy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922) and controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200928). The three groups were compared for level of burden in their carers by using the Zarit Burden Interview. The PD participants were rated for levels of apathy, impulsivity and motor and psychiatric symptoms. Using a multivariate analysis, we sought the PD\u2010related predictors of carer burden.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significantly, greater burden was seen in carers of PD participants with ICDs (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) or apathy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), compared with carers of PD participants without such behavioural disturbances. Linear regression models revealed that attentional ability accounted for burden in carers of the group with apathy, whereas dopaminergic load and depression accounted for burden in carers of the group with impulsivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PD\u2010related behaviour disturbances, such as apathy and ICDs, as well as psychiatric complications, have significant negative implications for burden of care. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/gps.2704","type":"journal-article","created":{"date-parts":[[2011,4,2]],"date-time":"2011-04-02T01:41:34Z","timestamp":1301708494000},"page":"160-166","source":"Crossref","is-referenced-by-count":139,"title":["Carer burden in apathy and impulse control disorders in Parkinson's disease"],"prefix":"10.1002","volume":"27","author":[{"given":"Iracema","family":"Leroi","sequence":"first","affiliation":[{"name":"University of Manchester  UK"},{"name":"Lancashire Care NHS Foundation Trust  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Harbishettar","sequence":"additional","affiliation":[{"name":"University of Leeds  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Andrews","sequence":"additional","affiliation":[{"name":"Lancashire Care NHS Foundation Trust  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"McDonald","sequence":"additional","affiliation":[{"name":"University of Manchester  UK"},{"name":"Salford Royal NHS Foundation Trust  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Jane","family":"Byrne","sequence":"additional","affiliation":[{"name":"University of Manchester  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair","family":"Burns","sequence":"additional","affiliation":[{"name":"University of Manchester  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.083113"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199910)14:10<866::AID-GPS38>3.0.CO;2-Z"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.67.4.492"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.072983"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21686"},{"issue":"4","key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1682\/JRRD.2005.08.1365","article-title":"Caregiver distress in Parkinsonism","volume":"43","author":"Cifu DX","year":"2006","journal-title":"J Rehabil Res Dev"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-009-0024-z"},{"key":"e_1_2_7_9_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"DSM IV TR APA","year":"2000"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21507"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00818.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.4.423"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/63.6.P372"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/31.5.349"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0714980800012484"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.427"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1998.tb02542.x"},{"key":"e_1_2_7_20_1","unstructured":"LeroiI AhearnDJ AndrewsM et al.2010.Disability and quality of life in Parkinson's disease is strongly associated with behavioural disordersEuropean Union of Geriatric Medicine Society meeting Dublin October (abstract)."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.144.9.1184"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1444.006"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(91)90040-V"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21355"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/28.1.35"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199603)11:3<263::AID-GPS316>3.0.CO;2-P"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(199511)51:6<768::AID-JCLP2270510607>3.0.CO;2-1"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2008.07.006"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.73.6.636"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.755"},{"key":"e_1_2_7_31_1","unstructured":"SPSS Inc.2007. [Computer software].SPSS version 16 Author Chicago Ill USA."},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.4.2.134"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000238503.20816.13"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32826fbc8f"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(09)70794-1"},{"key":"e_1_2_7_36_1","unstructured":"Williams\u2010GrayCH FoltynieT BrayneCEG RobbinsTW BarkerRA.2007.Evolution of cognitive dysfunction in an incident Parkinson's disease cohort Brain. Advance Access published on May 29."},{"key":"e_1_2_7_37_1","volume-title":"The Hidden Victims of Alzheimer's Disease: Families under Stress","author":"Zarit SH","year":"1985"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/20.6.649"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/26.3.260"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgps.2704","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.2704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T07:09:33Z","timestamp":1700550573000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.2704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1002\/gps.2704"],"URL":"https:\/\/doi.org\/10.1002\/gps.2704","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,2]]}}}