{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:17:43Z","timestamp":1791062263543,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,1,4]],"date-time":"2012-01-04T00:00:00Z","timestamp":1325635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Both apolipoprotein E (ApoE) \u03b5\u20104 allele(s) and elevated trait neuroticism, the tendency to experience distress, are associated with cognitive function among older adults. We predicted that neuroticism moderates the association between ApoE and cognitive function and also explored whether other personality dimensions (openness to experience, agreeableness, extraversion, and conscientiousness) affect the association between ApoE status and cognitive function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Five\u2010hundred and ninety\u2010seven older adults (mean age of 78\u2009years) enrolled in the Ginkgo Evaluation of Memory study completed the NEO five\u2010factor inventory of personality. Cognitive function was assessed via the cognitive portion of the Alzheimer's Disease Assessment Scale, and a blood sample for ApoE genotyping was drawn.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      As hypothesized, regression analysis indicated that neuroticism moderated the relationship between the presence of ApoE \u03b5\u20104 and cognitive function. Individuals with high neuroticism scores had significantly lower scores on the cognitive portion of the Alzheimer's Disease Assessment Scale compared with individuals with low neuroticism scores, but this was true only among carriers of ApoE \u03b5\u20104 (interaction effect\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.124,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028). There was scant evidence that other personality dimensions moderate the association between ApoE \u03b5\u20104 and cognitive function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cognitive function may be affected by ApoE and neuroticism acting in tandem. Research on the underlying physiological mechanisms by which neuroticism amplifies the effect of ApoE \u03b5\u20104 is warranted. The study of genotype by phenotype interactions provides an important and useful direction for the study of cognitive function among older adults and for the development of novel prevention programs. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/gps.3759","type":"journal-article","created":{"date-parts":[[2012,1,4]],"date-time":"2012-01-04T21:00:13Z","timestamp":1325710813000},"page":"1147-1154","source":"Crossref","is-referenced-by-count":17,"title":["Gene by neuroticism interaction and cognitive function among older adults"],"prefix":"10.1002","volume":"27","author":[{"given":"Ilan","family":"Dar\u2010Nimrod","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Laboratory of Personality and Development University of Rochester Medical Center  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin P.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Laboratory of Personality and Development University of Rochester Medical Center  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John 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