{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:43:58Z","timestamp":1786977838399,"version":"build-2736575974"},"reference-count":89,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,3,13]],"date-time":"2012-03-13T00:00:00Z","timestamp":1331596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Associations between vascular disease and depression in late life, including increased white matter hyperintensities (WMHs), have been reported. Whether depression is an etiology or a consequence of vascular disease is still unknown. We investigated the temporal relationship between depressive symptoms and WMHs in older men and women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We utilized data from 90 dementia\u2010free older adults (39 women, 51 men), 57\u2009years of age and older at baseline, from the neuroimaging substudy of the Baltimore Longitudinal Study of Aging. Participants were followed for up to 8\u2009years. Ratings of white matter disease burden were available for the first, last, and at least one interim visit, and participants completed the Center for Epidemiologic Studies Depression Scale (CES\u2010D) annually. Statistical models, performed separately in men and women, examined whether depressive symptoms predicted subsequent WMH ratings or WMHs predicted subsequent depressive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The total CES\u2010D score was not associated with WMHs in men or women. In men, the CES\u2010D depressed mood subscale predicted accelerating longitudinal increases in WMHs at older ages, but WMHs did not predict subsequent depressive symptoms. In women, there were no significant associations between the CES\u2010D depressed mood subscale and WMHs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>White matter disease may be a consequence of depressed mood in men but not in women. Intervention strategies for depression may slow the progression of white matter disease in older men. These results add to previous findings documenting sex differences in the correlates of depressive disorders in late life. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/gps.3791","type":"journal-article","created":{"date-parts":[[2012,3,13]],"date-time":"2012-03-13T08:22:58Z","timestamp":1331626978000},"page":"66-74","source":"Crossref","is-referenced-by-count":26,"title":["Temporal relationships between depressive symptoms and white matter hyperintensities in older men and women"],"prefix":"10.1002","volume":"28","author":[{"given":"Vonetta M.","family":"Dotson","sequence":"first","affiliation":[{"name":"Laboratory of Personality and Cognition, Intramural Research Program National Institute on Aging, National Institutes of Health  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan B.","family":"Zonderman","sequence":"additional","affiliation":[{"name":"Laboratory of Personality and Cognition, Intramural Research Program National Institute on Aging, National Institutes of Health  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Kraut","sequence":"additional","affiliation":[{"name":"Department of Radiology Johns Hopkins Medical Institutions  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Resnick","sequence":"additional","affiliation":[{"name":"Laboratory of Personality and Cognition, Intramural Research Program National Institute on Aging, National Institutes of Health  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532\u20135415.2003.51373.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.4.562"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20130447.2004.00297.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.052"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1255"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291796003510"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.166.3.320"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2003.08.003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610205002796"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20405"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291709991656"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2298"},{"key":"e_1_2_7_14_1","first-page":"367","article-title":"Depressive symptoms and brain volumes in older adults: a longitudinal magnetic resonance imaging study","volume":"34","author":"Dotson VM","year":"2009","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3181662a9c"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079\u20136123(00)26027\u20135"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.10.1133"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.40.10.1018"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199901000-00006"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532\u20135415.2003.51352.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.3.613"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.11.1071"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(93)90030-N"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1130"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040\u20103590.2.1.64"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20103223(96)00363\u20100"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.2.153"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajgp.13.2.88"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20103223(94)91219\u2010X"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.11.2072"},{"key":"e_1_2_7_31_1","first-page":"403","article-title":"Gender and cardiovascular risk","volume":"10","author":"Khaw KT","year":"1996","journal-title":"J Hum Hypertens"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajgp.13.3.202"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2007.02.001"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20103223(02)01349\u20105"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306\u20109877(95)90081\u20100"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20103223(02)01472\u20105"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.4.497"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1596"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20103223(95)00424\u20106"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-199705010-00003"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajgp.12.6.653"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-199911000-00006"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.10.1602"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.7.1119"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1996.tb02440.x"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300986"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.2.318"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.9.3.471"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-199622440-00002"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.2307\/2685902"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.55.7.580"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.153.10.1313"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.6.878"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.2009.02262.x"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.055129"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7164.982"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.168.4.477"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06403.x"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.181.5.406"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.11.2311"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.12.3123"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"e_1_2_7_64_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.31887\/DCNS.2007.9.1\/areichenberg","article-title":"Neuropsychiatric consequences of coronary artery bypass grafting and noncardiovascular surgery","volume":"9","author":"Reichenberg A","year":"2007","journal-title":"Dialogues Clin Neurosci"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.5.464"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.08.023"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810130062009"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1444.017"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610297004432"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.10.2159"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000018405.59799.D5"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291702007201"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e318048a1a0"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2005.08.003"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278\u20105846(02)00358\u20105"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.11.1090"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.7.1293"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2004.08.004"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291709990857"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.107.036756"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.70.1.83"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165\u20100327(02)00349\u2010X"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.4.369"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1477"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100447.2002.02245.x"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.3.289"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3181d57a2b"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.2004.52217.x"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.202.1.8988189"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.12.1818"}],"container-title":["International Journal of Geriatric Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgps.3791","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gps.3791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T20:46:21Z","timestamp":1700599581000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gps.3791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,13]]},"references-count":89,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1002\/gps.3791"],"URL":"https:\/\/doi.org\/10.1002\/gps.3791","archive":["Portico"],"relation":{},"ISSN":["0885-6230","1099-1166"],"issn-type":[{"value":"0885-6230","type":"print"},{"value":"1099-1166","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,13]]}}}