{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:16:43Z","timestamp":1791080203582,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T00:00:00Z","timestamp":1337126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Geriat Psychiatry"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to estimate several subtypes of depressive disorders as risk factors for dementia and Alzheimer disease (AD) specifically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a population\u2010based cohort study using a sample of 451 non\u2010demented older people. Adjusted Cox proportional hazard models were calculated to determine the association of depression with dementia or AD development after 5\u2009years. Baseline evaluation included the Cambridge Mental Disorders of the Elderly Examination (CAMDEX). Depressive disorders (major episode [MD] and minor depressive disorders [MDDIS]) were assessed following DSM\u2010IV criteria and further classified according to the age at onset (early versus late onset). In turn, all late\u2010onset depressions were grouped as with or without depression\u2010executive dysfunction syndrome (DEDS). Dementia (and dementia subtypes) diagnoses were made using the CAMDEX. When the patients were deceased, the Retrospective Collateral Dementia Interview was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Late\u2010onset depressions (both MD and MDDIS) were associated with increased dementia (hazard ratio [HR]\u2009=\u20092.635; 95% CI\u2009=\u20091.153\u20136.023; and HR\u2009=\u20092.517; 95% CI\u2009=\u20091.200\u20135.280, respectively), and AD (HR\u2009=\u20096.262; 95% CI\u2009=\u20092.017\u201319.446; and HR\u2009=\u20094.208; 95% CI\u2009=\u20091.828\u20139.685, respectively) after adjustment by age, gender, marital status, education, cognitive impairment, executive function and stroke history. A second model revealed that only late\u2010onset depressions with DEDS increased the risk for both dementia (late\u2010onset MD with DEDS: HR\u2009=\u20096.262; 95% CI\u2009=\u20092.017\u201319.446; late\u2010onset MDDIS with DEDS: HR\u2009=\u20094.208; 95% CI\u2009=\u20091.828\u20139.685) and AD (late\u2010onset MD with DEDS: HR\u2009=\u20097.807; 95% CI\u2009=\u20091.567\u201338.894; late\u2010onset MDDIS with DEDS: HR\u2009=\u20096.099; 95% CI\u2009=\u20092.123\u201317.524).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Late\u2010onset depressive episodes with DEDS are risk factors for dementia and AD development, regardless of the severity of the depression. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gps.3826","type":"journal-article","created":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T06:13:53Z","timestamp":1337148833000},"page":"341-350","source":"Crossref","is-referenced-by-count":51,"title":["Depression subtypes and 5\u2010year risk of dementia and Alzheimer disease in patients aged 70\u2009years"],"prefix":"10.1002","volume":"28","author":[{"given":"Joan","family":"Vilalta\u2010Franch","sequence":"first","affiliation":[{"name":"Research Unit Institut d'Assist\u00e8ncia Sanit\u00e0ria Salt Girona Spain"},{"name":"Dementia Unit Hospital de Santa Caterina Salt Girona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Secundino","family":"L\u00f3pez\u2010Pousa","sequence":"additional","affiliation":[{"name":"Research Unit Institut d'Assist\u00e8ncia Sanit\u00e0ria Salt Girona Spain"},{"name":"Dementia Unit Hospital de Santa Caterina Salt Girona 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